node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IlvH | Rru_A0284 | Rru_A0468 | Rru_A0284 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.998 |
IlvH | Rru_A0467 | Rru_A0468 | Rru_A0467 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
IlvH | Rru_A0647 | Rru_A0468 | Rru_A0647 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase. | 0.973 |
IlvH | Rru_A2269 | Rru_A0468 | Rru_A2269 | Acetolactate synthase, small subunit. | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.687 |
IlvH | Rru_A2877 | Rru_A0468 | Rru_A2877 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase. | 0.972 |
IlvH | ilvC | Rru_A0468 | Rru_A0469 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
IlvH | ilvD | Rru_A0468 | Rru_A1786 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.942 |
IlvH | leuB | Rru_A0468 | Rru_A1191 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.993 |
IlvH | leuC | Rru_A0468 | Rru_A1189 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.917 |
IlvH | leuD | Rru_A0468 | Rru_A1190 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.921 |
Rru_A0284 | IlvH | Rru_A0284 | Rru_A0468 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.998 |
Rru_A0284 | Rru_A0467 | Rru_A0284 | Rru_A0467 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.923 |
Rru_A0284 | Rru_A0647 | Rru_A0284 | Rru_A0647 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase. | 0.941 |
Rru_A0284 | Rru_A2269 | Rru_A0284 | Rru_A2269 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.720 |
Rru_A0284 | Rru_A2877 | Rru_A0284 | Rru_A2877 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase. | 0.957 |
Rru_A0284 | ilvC | Rru_A0284 | Rru_A0469 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.991 |
Rru_A0284 | ilvD | Rru_A0284 | Rru_A1786 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.890 |
Rru_A0284 | leuB | Rru_A0284 | Rru_A1191 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.971 |
Rru_A0284 | leuC | Rru_A0284 | Rru_A1189 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.684 |
Rru_A0284 | leuD | Rru_A0284 | Rru_A1190 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.738 |