node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rru_A0299 | Rru_A2483 | Rru_A0299 | Rru_A2483 | Glutamine amidotransferase class-I. | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | 0.963 |
Rru_A0299 | Rru_A3319 | Rru_A0299 | Rru_A3319 | Glutamine amidotransferase class-I. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.928 |
Rru_A0299 | Rru_A3512 | Rru_A0299 | Rru_A3512 | Glutamine amidotransferase class-I. | Glutamine amidotransferase class-I. | 0.922 |
Rru_A0299 | Rru_A3640 | Rru_A0299 | Rru_A3640 | Glutamine amidotransferase class-I. | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.908 |
Rru_A0299 | guaA | Rru_A0299 | Rru_A0355 | Glutamine amidotransferase class-I. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.912 |
Rru_A0299 | guaB | Rru_A0299 | Rru_A0244 | Glutamine amidotransferase class-I. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.987 |
Rru_A0299 | surE | Rru_A0299 | Rru_A1769 | Glutamine amidotransferase class-I. | 5'-nucleotidase / exopolyphosphatase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
Rru_A2483 | Rru_A0299 | Rru_A2483 | Rru_A0299 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | Glutamine amidotransferase class-I. | 0.963 |
Rru_A2483 | Rru_A3319 | Rru_A2483 | Rru_A3319 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.913 |
Rru_A2483 | Rru_A3512 | Rru_A2483 | Rru_A3512 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | Glutamine amidotransferase class-I. | 0.901 |
Rru_A2483 | Rru_A3640 | Rru_A2483 | Rru_A3640 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.901 |
Rru_A2483 | guaA | Rru_A2483 | Rru_A0355 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.913 |
Rru_A2483 | guaB | Rru_A2483 | Rru_A0244 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.931 |
Rru_A2483 | surE | Rru_A2483 | Rru_A1769 | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase / exopolyphosphatase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.923 |
Rru_A3319 | Rru_A0299 | Rru_A3319 | Rru_A0299 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Glutamine amidotransferase class-I. | 0.928 |
Rru_A3319 | Rru_A2483 | Rru_A3319 | Rru_A2483 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | 0.913 |
Rru_A3319 | Rru_A3512 | Rru_A3319 | Rru_A3512 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Glutamine amidotransferase class-I. | 0.928 |
Rru_A3319 | Rru_A3640 | Rru_A3319 | Rru_A3640 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.921 |
Rru_A3319 | guaA | Rru_A3319 | Rru_A0355 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.990 |
Rru_A3319 | guaB | Rru_A3319 | Rru_A0244 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.954 |