node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAZ69263.1 | AAZ72146.1 | Mbar_A0279 | Mbar_A3265 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | 0.636 |
AAZ69263.1 | argS | Mbar_A0279 | Mbar_A1008 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.818 |
AAZ69263.1 | hisS | Mbar_A0279 | Mbar_A3452 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.481 |
AAZ69263.1 | leuS | Mbar_A0279 | Mbar_A2048 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.950 |
AAZ69263.1 | metG | Mbar_A0279 | Mbar_A0543 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.713 |
AAZ69263.1 | sepS | Mbar_A0279 | Mbar_A1204 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | phosphoserine-tRNA(Cys) ligase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys). | 0.467 |
AAZ69263.1 | serS1 | Mbar_A0279 | Mbar_A0541 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. | 0.920 |
AAZ69263.1 | serS2 | Mbar_A0279 | Mbar_A2126 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). | 0.900 |
AAZ69263.1 | thrS | Mbar_A0279 | Mbar_A2945 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | threonyl-tRNA synthetase / Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.977 |
AAZ72146.1 | AAZ69263.1 | Mbar_A3265 | Mbar_A0279 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | 0.636 |
AAZ72146.1 | argS | Mbar_A3265 | Mbar_A1008 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.861 |
AAZ72146.1 | hisS | Mbar_A3265 | Mbar_A3452 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.434 |
AAZ72146.1 | serS1 | Mbar_A3265 | Mbar_A0541 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. | 0.854 |
AAZ72146.1 | serS2 | Mbar_A3265 | Mbar_A2126 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). | 0.854 |
AAZ72146.1 | thrS | Mbar_A3265 | Mbar_A2945 | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | threonyl-tRNA synthetase / Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.595 |
argS | AAZ69263.1 | Mbar_A1008 | Mbar_A0279 | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...] | 0.818 |
argS | AAZ72146.1 | Mbar_A1008 | Mbar_A3265 | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Sodium/proton antiporter, CPA1 family; TC 2.A.36. | 0.861 |
argS | hisS | Mbar_A1008 | Mbar_A3452 | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.931 |
argS | leuS | Mbar_A1008 | Mbar_A2048 | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.981 |
argS | lysS-2 | Mbar_A1008 | Mbar_A1667 | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.966 |