node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAZ69551.1 | AAZ70258.1 | Mbar_A0571 | Mbar_A1295 | IMP cyclohydrolase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.996 |
AAZ69551.1 | AAZ71241.1 | Mbar_A0571 | Mbar_A2317 | IMP cyclohydrolase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.999 |
AAZ69551.1 | folD | Mbar_A0571 | Mbar_A2315 | IMP cyclohydrolase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
AAZ69551.1 | glyA | Mbar_A0571 | Mbar_A2316 | IMP cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Appears to be specific for THF as the pteridine substrate, since the use of tetrahydromethanopterin (H4MPT) is much less efficient. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family. | 0.998 |
AAZ69551.1 | purC | Mbar_A0571 | Mbar_A0531 | IMP cyclohydrolase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.974 |
AAZ69551.1 | purD | Mbar_A0571 | Mbar_A3513 | IMP cyclohydrolase. | Phosphoribosylamine--glycine ligase. | 0.999 |
AAZ69551.1 | purF | Mbar_A0571 | Mbar_A3498 | IMP cyclohydrolase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
AAZ69551.1 | purL | Mbar_A0571 | Mbar_A0536 | IMP cyclohydrolase. | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.999 |
AAZ69551.1 | thyA | Mbar_A0571 | Mbar_A0890 | IMP cyclohydrolase. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.637 |
AAZ70258.1 | AAZ69551.1 | Mbar_A1295 | Mbar_A0571 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | IMP cyclohydrolase. | 0.996 |
AAZ70258.1 | AAZ71241.1 | Mbar_A1295 | Mbar_A2317 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.908 |
AAZ70258.1 | folD | Mbar_A1295 | Mbar_A2315 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
AAZ70258.1 | glyA | Mbar_A1295 | Mbar_A2316 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Appears to be specific for THF as the pteridine substrate, since the use of tetrahydromethanopterin (H4MPT) is much less efficient. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family. | 0.960 |
AAZ70258.1 | purC | Mbar_A1295 | Mbar_A0531 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.805 |
AAZ70258.1 | purD | Mbar_A1295 | Mbar_A3513 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Phosphoribosylamine--glycine ligase. | 0.999 |
AAZ70258.1 | purF | Mbar_A1295 | Mbar_A3498 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.914 |
AAZ70258.1 | purL | Mbar_A1295 | Mbar_A0536 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.983 |
AAZ71241.1 | AAZ69551.1 | Mbar_A2317 | Mbar_A0571 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | IMP cyclohydrolase. | 0.999 |
AAZ71241.1 | AAZ70258.1 | Mbar_A2317 | Mbar_A1295 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.908 |
AAZ71241.1 | folD | Mbar_A2317 | Mbar_A2315 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |