STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaJ-2DNAJ-like chaperone; heat shock protein. (211 aa)    
Predicted Functional Partners:
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
   0.906
yegD
Probable heat shock protein.
  
 0.875
dnaK
Chaperone protein (heat shock protein 70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.875
tpn50
Outer membrane protein, OmpA family.
  
 
 0.849
groEL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.835
htpG
Heat shock protein (chaperone Hsp90); Molecular chaperone. Has ATPase activity.
  
 0.807
CHU_2948
Conserved hypothetical protein.
  
 0.807
grpE
Molecular chaperone, heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Severa [...]
  
 
 0.758
rplQ
LSU ribosomal protein L17P.
  
   0.751
fabG
3-oxoacyl-[acyl-carrier-protein] reductase.
  
   0.742
Your Current Organism:
Cytophaga hutchinsonii
NCBI taxonomy Id: 269798
Other names: C. hutchinsonii ATCC 33406, Cytophaga hutchinsonii ATCC 33406, Cytophaga hutchinsonii str. ATCC 33406, Cytophaga hutchinsonii strain ATCC 33406
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.