node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gmet_1179 | folD-2 | Gmet_1179 | Gmet_1162 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 5,10-methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.922 |
Gmet_1179 | glyA | Gmet_1179 | Gmet_1605 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.465 |
Gmet_1179 | metF-2 | Gmet_1179 | Gmet_0504 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase. | 0.454 |
Gmet_1179 | purN | Gmet_1179 | Gmet_1845 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase, folate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.929 |
Gmet_2025 | arnG | Gmet_2025 | Gmet_0884 | Hypothetical protein. | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | 0.922 |
Gmet_2025 | fmt | Gmet_2025 | Gmet_3339 | Hypothetical protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.923 |
Gmet_2025 | folD-2 | Gmet_2025 | Gmet_1162 | Hypothetical protein. | 5,10-methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
Gmet_2025 | gcvT | Gmet_2025 | Gmet_3155 | Hypothetical protein. | Glycine cleavage system T protein. | 0.915 |
Gmet_2025 | glyA | Gmet_2025 | Gmet_1605 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
Gmet_2025 | metF-2 | Gmet_2025 | Gmet_0504 | Hypothetical protein. | Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase. | 0.930 |
Gmet_2025 | purN | Gmet_2025 | Gmet_1845 | Hypothetical protein. | Phosphoribosylglycinamide formyltransferase, folate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
Gmet_2025 | thyX | Gmet_2025 | Gmet_0378 | Hypothetical protein. | Thymidylate synthase, FAD-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |
arnG | Gmet_2025 | Gmet_0884 | Gmet_2025 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Hypothetical protein. | 0.922 |
arnG | fmt | Gmet_0884 | Gmet_3339 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
arnG | folD-2 | Gmet_0884 | Gmet_1162 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | 5,10-methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
arnG | gcvT | Gmet_0884 | Gmet_3155 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Glycine cleavage system T protein. | 0.915 |
arnG | glyA | Gmet_0884 | Gmet_1605 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
arnG | metF-2 | Gmet_0884 | Gmet_0504 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase. | 0.930 |
arnG | purN | Gmet_0884 | Gmet_1845 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Phosphoribosylglycinamide formyltransferase, folate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
arnG | thyX | Gmet_0884 | Gmet_0378 | UDP-4-amino-4-deoxy-L-arabinose formyltransferase. | Thymidylate synthase, FAD-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |