node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tfu_0071 | Tfu_1796 | Tfu_0071 | Tfu_1796 | Conserved hypothetical protein. | Putative proteasome component. | 0.559 |
Tfu_0071 | arc | Tfu_0071 | Tfu_1809 | Conserved hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.772 |
Tfu_0071 | pafA | Tfu_0071 | Tfu_1788 | Conserved hypothetical protein. | Conserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.644 |
Tfu_0071 | prcA | Tfu_0071 | Tfu_1789 | Conserved hypothetical protein. | Putative 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.997 |
Tfu_0071 | prcB | Tfu_0071 | Tfu_1790 | Conserved hypothetical protein. | Bacterial proteasome, beta component. Threonine peptidase. MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.919 |
Tfu_0071 | pup | Tfu_0071 | Tfu_1791 | Conserved hypothetical protein. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.712 |
Tfu_1771 | Tfu_1796 | Tfu_1771 | Tfu_1796 | Similar to transcriptional regulator. | Putative proteasome component. | 0.425 |
Tfu_1771 | arc | Tfu_1771 | Tfu_1809 | Similar to transcriptional regulator. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.540 |
Tfu_1771 | pafA | Tfu_1771 | Tfu_1788 | Similar to transcriptional regulator. | Conserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.883 |
Tfu_1771 | prcA | Tfu_1771 | Tfu_1789 | Similar to transcriptional regulator. | Putative 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.644 |
Tfu_1771 | prcB | Tfu_1771 | Tfu_1790 | Similar to transcriptional regulator. | Bacterial proteasome, beta component. Threonine peptidase. MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.445 |
Tfu_1771 | pup | Tfu_1771 | Tfu_1791 | Similar to transcriptional regulator. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.473 |
Tfu_1796 | Tfu_0071 | Tfu_1796 | Tfu_0071 | Putative proteasome component. | Conserved hypothetical protein. | 0.559 |
Tfu_1796 | Tfu_1771 | Tfu_1796 | Tfu_1771 | Putative proteasome component. | Similar to transcriptional regulator. | 0.425 |
Tfu_1796 | arc | Tfu_1796 | Tfu_1809 | Putative proteasome component. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.923 |
Tfu_1796 | prcA | Tfu_1796 | Tfu_1789 | Putative proteasome component. | Putative 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.892 |
Tfu_1796 | prcB | Tfu_1796 | Tfu_1790 | Putative proteasome component. | Bacterial proteasome, beta component. Threonine peptidase. MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.884 |
Tfu_1796 | pup | Tfu_1796 | Tfu_1791 | Putative proteasome component. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.876 |
Tfu_2144 | Tfu_2370 | Tfu_2144 | Tfu_2370 | ATPase. | Mov34/MPN/PAD-1. | 0.549 |
Tfu_2144 | arc | Tfu_2144 | Tfu_1809 | ATPase. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.584 |