node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0306.1 | APE_0681.1 | APE_0306.1 | APE_0681.1 | Putative carbohydrate kinase. | Conserved hypothetical protein. | 0.994 |
APE_0306.1 | pan | APE_0306.1 | APE_2012 | Putative carbohydrate kinase. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.995 |
APE_0306.1 | psmA | APE_0306.1 | APE_1449 | Putative carbohydrate kinase. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
APE_0306.1 | psmB | APE_0306.1 | APE_0507.1 | Putative carbohydrate kinase. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
APE_0306.1 | psmB-2 | APE_0306.1 | APE_0521.1 | Putative carbohydrate kinase. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.901 |
APE_0306.1 | rpl40e | APE_0306.1 | APE_0113a | Putative carbohydrate kinase. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.899 |
APE_0681.1 | APE_0306.1 | APE_0681.1 | APE_0306.1 | Conserved hypothetical protein. | Putative carbohydrate kinase. | 0.994 |
APE_0681.1 | pan | APE_0681.1 | APE_2012 | Conserved hypothetical protein. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.998 |
APE_0681.1 | psmA | APE_0681.1 | APE_1449 | Conserved hypothetical protein. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
APE_0681.1 | psmB | APE_0681.1 | APE_0507.1 | Conserved hypothetical protein. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
APE_0681.1 | psmB-2 | APE_0681.1 | APE_0521.1 | Conserved hypothetical protein. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.898 |
APE_0681.1 | rpl40e | APE_0681.1 | APE_0113a | Conserved hypothetical protein. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.941 |
ef1b | psmA | APE_2480.1 | APE_1449 | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.618 |
ef1b | psmB | APE_2480.1 | APE_0507.1 | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.618 |
ef1b | psmB-2 | APE_2480.1 | APE_0521.1 | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.618 |
ef1b | rpl40e | APE_2480.1 | APE_0113a | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.948 |
nfi | psmB | APE_0506 | APE_0507.1 | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. | Proteasome beta subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.657 |
pan | APE_0306.1 | APE_2012 | APE_0306.1 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Putative carbohydrate kinase. | 0.995 |
pan | APE_0681.1 | APE_2012 | APE_0681.1 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Conserved hypothetical protein. | 0.998 |
pan | psmA | APE_2012 | APE_1449 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.954 |