STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)    
Predicted Functional Partners:
gltA
Citrate synthase.
  
 0.994
fumC
Fumarate hydratase class II.
  
 0.986
aspC
Aspartate aminotransferase; Transaminase A.
  
 0.967
pckA
Phosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
 
 
 0.957
APE_0689.1
Isocitrate dehydrogenase [NADP]; NADP-IDH.
  
 
 0.954
APE_0392
Malate dehydrogenase; Malic enzyme.
  
 0.951
aspC-2
Aspartate aminotransferase; Transaminase A.
  
 0.937
gap
Glyceraldehyde 3-phosphate dehydrogenase; GAPDH.
  
 
 0.910
gdhA
NADP-dependent glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.910
sdhB
Succinate dehydrogenase subunit B.
  
 
 0.901
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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