node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0791.1 | eif5a | APE_0791.1 | APE_2085.1 | Putative ATP/GTP-binding protein. | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.459 |
APE_0791.1 | fen | APE_0791.1 | APE_0115.1 | Putative ATP/GTP-binding protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.431 |
APE_0791.1 | psmA | APE_0791.1 | APE_1449 | Putative ATP/GTP-binding protein. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.532 |
APE_0791.1 | rpl4p | APE_0791.1 | APE_0228.1 | Putative ATP/GTP-binding protein. | 50S ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.432 |
APE_0791.1 | tbp | APE_0791.1 | APE_1862.1 | Putative ATP/GTP-binding protein. | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.438 |
APE_0791.1 | thsA | APE_0791.1 | APE_0907.1 | Putative ATP/GTP-binding protein. | Thermosome alpha subunit; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. | 0.737 |
APE_0791.1 | thsB | APE_0791.1 | APE_2072.1 | Putative ATP/GTP-binding protein. | Thermosome beta subunit; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. | 0.717 |
aif2b | eif5a | APE_1533.1 | APE_2085.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.549 |
aif2b | fen | APE_1533.1 | APE_0115.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.647 |
aif2b | psmA | APE_1533.1 | APE_1449 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.687 |
aif2b | rpl4p | APE_1533.1 | APE_0228.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | 50S ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.736 |
aif2b | tbp | APE_1533.1 | APE_1862.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.516 |
aif2b | thsA | APE_1533.1 | APE_0907.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | Thermosome alpha subunit; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. | 0.743 |
aif2b | thsB | APE_1533.1 | APE_2072.1 | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | Thermosome beta subunit; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family. | 0.722 |
eif5a | APE_0791.1 | APE_2085.1 | APE_0791.1 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | Putative ATP/GTP-binding protein. | 0.459 |
eif5a | aif2b | APE_2085.1 | APE_1533.1 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the eIF-2-beta/eIF-5 family. | 0.549 |
eif5a | fen | APE_2085.1 | APE_0115.1 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.625 |
eif5a | psmA | APE_2085.1 | APE_1449 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.600 |
eif5a | rpl4p | APE_2085.1 | APE_0228.1 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 50S ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.799 |
eif5a | tbp | APE_2085.1 | APE_1862.1 | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.604 |