STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemL-2Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (429 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.999
hemB
Porphobilinogen synthase; ALADH; delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.994
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.973
hemL
Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.909
APE_0188.1
Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family.
      
 0.785
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
     
 0.678
lysC
Aspartate kinase; Belongs to the aspartokinase family.
 
  
 0.633
APE_2295.1
Conserved hypothetical protein.
       0.605
gltA
Citrate synthase.
  
  
 0.590
rfbD
dTDP-4-dehydrorhamnose reductase; RmlD.
  
    0.574
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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