node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysK | pyrF | APE_1586 | APE_2348 | Cysteine synthase; Cysteine synthase that can also catalyze the synthesis of S- sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide. Belongs to the cysteine synthase/cystathionine beta- synthase family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.856 |
cysK | trpA | APE_1586 | APE_2550 | Cysteine synthase; Cysteine synthase that can also catalyze the synthesis of S- sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide. Belongs to the cysteine synthase/cystathionine beta- synthase family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.924 |
pyrB | pyrC | APE_1663.1 | APE_0261.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrD | APE_1663.1 | APE_0260.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.986 |
pyrB | pyrE | APE_1663.1 | APE_2349.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.984 |
pyrB | pyrF | APE_1663.1 | APE_2348 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.984 |
pyrB | pyrH | APE_1663.1 | APE_0401.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.550 |
pyrB | pyrI | APE_1663.1 | APE_1662.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.999 |
pyrB | surE | APE_1663.1 | APE_0801.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | 5'(3')-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.462 |
pyrB | upp | APE_1663.1 | APE_0545.1 | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.802 |
pyrC | pyrB | APE_0261.1 | APE_1663.1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | 0.999 |
pyrC | pyrD | APE_0261.1 | APE_0260.1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.999 |
pyrC | pyrE | APE_0261.1 | APE_2349.1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.986 |
pyrC | pyrF | APE_0261.1 | APE_2348 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.984 |
pyrC | pyrI | APE_0261.1 | APE_1662.1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.946 |
pyrD | pyrB | APE_0260.1 | APE_1663.1 | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Aspartate carbamoyltransferase, catalytic subunit; ATCase. | 0.986 |
pyrD | pyrC | APE_0260.1 | APE_0261.1 | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrD | pyrE | APE_0260.1 | APE_2349.1 | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.998 |
pyrD | pyrF | APE_0260.1 | APE_2348 | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.986 |
pyrD | pyrH | APE_0260.1 | APE_0401.1 | Probable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.531 |