STRINGSTRING
pyrF protein (Aeropyrum pernix) - STRING interaction network
"pyrF" - Orotidine 5'-phosphate decarboxylase in Aeropyrum pernix
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrFOrotidine 5’-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5’- monophosphate (OMP) to uridine 5’-monophosphate (UMP) (244 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (186 aa)
   
  0.999
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP (225 aa)
   
 
  0.989
cmk
Cytidylate kinase (172 aa)
       
    0.981
pyrB
Aspartate carbamoyltransferase catalytic subunit (308 aa)
   
 
  0.976
pyrD
Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor (306 aa)
   
  0.969
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (214 aa)
   
  0.956
pyrC
Dihydroorotase (425 aa)
   
 
  0.936
APE_1968
Carbamate kinase (316 aa)
       
  0.936
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (512 aa)
   
   
  0.934
APE_1404.1
3-phosphoshikimate 1-carboxyvinyltransferase (419 aa)
       
  0.917
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix, A. pernix K1, Aeropyrum, Aeropyrum pernix, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
Server load: low (14%) [HD]