node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BH0003 | BH0005 | gene:10725818 | gene:10725820 | BH0003; unknown conserved protein. | BH0005; unknown conserved protein. | 0.807 |
BH0003 | dnaA | gene:10725818 | gene:10725816 | BH0003; unknown conserved protein. | Initiation of chromosome replication; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | 0.610 |
BH0003 | dnaN | gene:10725818 | gene:10725817 | BH0003; unknown conserved protein. | DNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] | 0.789 |
BH0003 | gyrB | gene:10725818 | gene:10725821 | BH0003; unknown conserved protein. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.649 |
BH0003 | recF | gene:10725818 | gene:10725819 | BH0003; unknown conserved protein. | DNA repair and genetic recombination; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.928 |
BH0005 | BH0003 | gene:10725820 | gene:10725818 | BH0005; unknown conserved protein. | BH0003; unknown conserved protein. | 0.807 |
BH0005 | dnaN | gene:10725820 | gene:10725817 | BH0005; unknown conserved protein. | DNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] | 0.568 |
BH0005 | gyrB | gene:10725820 | gene:10725821 | BH0005; unknown conserved protein. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.669 |
BH0005 | recF | gene:10725820 | gene:10725819 | BH0005; unknown conserved protein. | DNA repair and genetic recombination; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.842 |
BH0924 | BH1369 | gene:10726798 | gene:10727263 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.856 |
BH0924 | recF | gene:10726798 | gene:10725819 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | DNA repair and genetic recombination; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.724 |
BH0924 | recN | gene:10726798 | gene:10728676 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | DNA repair and genetic recombination; May be involved in recombinational repair of damaged DNA. | 0.799 |
BH0924 | ruvA | gene:10726798 | gene:10727118 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.754 |
BH1369 | BH0924 | gene:10727263 | gene:10726798 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.856 |
BH1369 | dnaN | gene:10727263 | gene:10725817 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | DNA polymerase III (beta subunit); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation o [...] | 0.641 |
BH1369 | gyrB | gene:10727263 | gene:10725821 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.477 |
BH1369 | recF | gene:10727263 | gene:10725819 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | DNA repair and genetic recombination; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.745 |
BH1369 | recN | gene:10727263 | gene:10728676 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | DNA repair and genetic recombination; May be involved in recombinational repair of damaged DNA. | 0.749 |
BH1369 | recR | gene:10727263 | gene:10725855 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | DNA repair and genetic recombination; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.957 |
BH1369 | ruvA | gene:10727263 | gene:10727118 | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.716 |