STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIIABAnti-sigma F factor (stage II sporulation protein AB); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)    
Predicted Functional Partners:
spoIIAA
Anti-sigma F factor antagonist (stage II sporulation protein AA); BH1536; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.998
sigF
RNA polymerase sigma-F factor (stage II sporulation protein AC); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 
 0.989
spoIIGA
Protease (processing of pro-sigma-E to active sigma-E); Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
  
  
 0.952
spoIIR
Stage II sporulation protein R; BH3773; required for processing of pro-sigma-E.
  
   
 0.921
spoIIID
Transcriptional regulator of sigma-E- and sigma-K-dependent; BH3740.
  
   
 0.920
spoVAC
Stage V sporulation protein AC; BH1539.
 
   
 0.883
spoVAD
Stage V sporulation protein AD; BH1540.
 
  
 0.872
spoVAE
Stage V sporulation protein AE; BH1541; divided.
 
     0.867
spoVAF
Stage V sporulation protein AF; BH1543.
 
   
 0.851
sigG
RNA polymerase sporulation forespore-specific (late) sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.849
Your Current Organism:
Bacillus halodurans
NCBI taxonomy Id: 272558
Other names: B. halodurans C-125, Bacillus halodurans C-125, Bacillus halodurans str. C-125, Bacillus halodurans strain C-125
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