node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BH1500 | BH1629 | gene:10727398 | gene:10727527 | Homoserine dehydrogenase; Belongs to the aspartokinase family. | BH1629; unknown conserved protein. | 0.694 |
BH1500 | BH3265 | gene:10727398 | gene:10729177 | Homoserine dehydrogenase; Belongs to the aspartokinase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.821 |
BH1500 | metH | gene:10727398 | gene:10727528 | Homoserine dehydrogenase; Belongs to the aspartokinase family. | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.546 |
BH1629 | BH1500 | gene:10727527 | gene:10727398 | BH1629; unknown conserved protein. | Homoserine dehydrogenase; Belongs to the aspartokinase family. | 0.694 |
BH1629 | BH2816 | gene:10727527 | gene:10728716 | BH1629; unknown conserved protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
BH1629 | BH3265 | gene:10727527 | gene:10729177 | BH1629; unknown conserved protein. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.948 |
BH1629 | dfrA | gene:10727527 | gene:10729363 | BH1629; unknown conserved protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.941 |
BH1629 | folD | gene:10727527 | gene:10728684 | BH1629; unknown conserved protein. | Methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
BH1629 | glyA | gene:10727527 | gene:10729678 | BH1629; unknown conserved protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
BH1629 | metH | gene:10727527 | gene:10727528 | BH1629; unknown conserved protein. | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
BH1629 | purN | gene:10727527 | gene:10726506 | BH1629; unknown conserved protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.949 |
BH2133 | BH3265 | gene:10728031 | gene:10729177 | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.842 |
BH2133 | BH3960 | gene:10728031 | gene:10729873 | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | Malate/quinone oxidoreductase. | 0.927 |
BH2816 | BH1629 | gene:10728716 | gene:10727527 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | BH1629; unknown conserved protein. | 0.959 |
BH2816 | BH3265 | gene:10728716 | gene:10729177 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.931 |
BH2816 | dfrA | gene:10728716 | gene:10729363 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.925 |
BH2816 | folD | gene:10728716 | gene:10728684 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
BH2816 | glyA | gene:10728716 | gene:10729678 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
BH2816 | metH | gene:10728716 | gene:10727528 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.955 |
BH2816 | purN | gene:10728716 | gene:10726506 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.935 |