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ileS protein (Bacteroides fragilis NCTC 9343) - STRING interaction network
"ileS" - Isoleucine--tRNA ligase in Bacteroides fragilis NCTC 9343
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily (1141 aa)    
Predicted Functional Partners:
leuS
Leucine--tRNA ligase; Similar to Bacillus subtilis leucyl-tRNA synthetase LeuS or BSU30320 SWALL-SYL_BACSU (SWALL-P36430) (804 aa) fasta scores- E()- 8.5e-35, 42.75% id in 945 aa, and to Bacteroides thetaiotaomicron leucyl-tRNA synthetase BT3126 SWALL-Q8A329 (EMBL-AE016939) (944 aa) fasta scores- E()- 0, 87.28% id in 944 aa, and to Porphyromonas gingivalis W83 leucyl-tRNA synthetase LeuS or PG0796 SWALL-AAQ65957 (EMBL-AE017174) (925 aa) fasta scores- E()- 9e-163, 69.57% id in 950 aa; Belongs to the class-I aminoacyl-tRNA synthetase family (943 aa)
 
 
  0.944
pheT
Phenylalanine--tRNA ligase beta subunit; Similar to Bacillus subtilis phenylalanyl-tRNA synthetase beta chain PheT SWALL-SYFB_BACSU (SWALL-P17922) (804 aa) fasta scores- E()- 7.1e-66, 35.57% id in 832 aa, and to Bacteroides thetaiotaomicron phenylalanyl-tRNA synthetase beta chain BT0626 SWALL-AAO75733 (EMBL-AE016928) (820 aa) fasta scores- E()- 0, 91.22% id in 820 aa (820 aa)
   
 
  0.938
glyS
Glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly); Belongs to the class-II aminoacyl-tRNA synthetase family (513 aa)
   
 
  0.919
cysS
Cysteine--tRNA ligase; Similar to Deinococcus radiodurans cysteinyl-tRNA synthetase CysS or dr1670 SWALL-SYC_DEIRA (SWALL-Q9RTT6) (498 aa) fasta scores- E()- 9.3e-82, 49.49% id in 495 aa, and to Bacteroides thetaiotaomicron cysteinyl-tRNA synthetase BT3351 SWALL-AAO78457 (EMBL-AE016940) (493 aa) fasta scores- E()- 2e-185, 90.06% id in 493 aa, and to Chlorobium tepidum cysteinyl-tRNA synthetase CysS or CT2158 SWALL-Q8KAK2 (EMBL-AE012964) (487 aa) fasta scores- E()- 6.3e-86, 48.79% id in 496 aa; Belongs to the class-I aminoacyl-tRNA synthetase family (491 aa)
 
   
  0.916
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction- proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (497 aa)
   
 
  0.877
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily (876 aa)
   
 
0.872
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (872 aa)
 
 
  0.871
argS
Arginine--tRNA ligase; Similar to Lactococcus lactis arginyl-tRNA synthetase ArgS or ll2038 SWALL-SYR_LACLA (SWALL-Q9CE12) (564 aa) fasta scores- E()- 1.4e-31, 30.16% id in 600 aa, and to Bacteroides thetaiotaomicron arginyl-tRNA synthetase BT2829 SWALL-Q8A3X5 (EMBL-AE016937) (597 aa) fasta scores- E()- 7.6e-216, 92.46% id in 597 aa, and to Porphyromonas gingivalis W83 arginyl-tRNA synthetase ArgS or PG0267 SWALL-AAQ65487 (EMBL-AE017172) (597 aa) fasta scores- E()- 2.8e-165, 71.18% id in 597 aa (597 aa)
 
 
  0.855
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1249 aa)
   
   
  0.851
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (679 aa)
 
 
  0.848
Your Current Organism:
Bacteroides fragilis NCTC 9343
NCBI taxonomy Id: 272559
Other names: B. fragilis NCTC 9343, Bacteroides fragilis ATCC 25285, Bacteroides fragilis NCTC 9343, Bacteroides fragilis str. NCTC 9343, Bacteroides fragilis strain NCTC 9343
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