STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (367 aa)    
Predicted Functional Partners:
BPSL1437
Similar to Escherichia coli DNA polymerase III, delta' subunit HolB or b1099 SWALL:HOLB_ECOLI (SWALL:P28631) (334 aa) fasta scores: E(): 4e-11, 34.82% id in 290 aa, and to Ralstonia solanacearum probable DNA polymerase III rsc1785 or rs04183 SWALL:Q8XYH3 (EMBL:AL646066) (336 aa) fasta scores: E(): 8.5e-47, 55.71% id in 341 aa.
 
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.999
dnaX
DNA polymerase III subunit gamma; Similar to the N-terminal region of Escherichia coli DNA polymerase III subunit tau DnaX or DnaZ or DnaZX or b0470 SWALL:DP3X_ECOLI (SWALL:P06710) (643 aa) fasta scores: E(): 1.4e-51, 46.7% id in 531 aa, and to the N-terminal region of Ralstonia solanacearum probable DNA polymerase III rsc1191 or rs05723 SWALL:Q8Y053 (EMBL:AL646063) (728 aa) fasta scores: E(): 9e-82, 54.42% id in 836 aa, and to the full length of Buchnera aphidicola DNA polymerase III subunit gamma DnaX or bu481 SWALL:DP3X_BUCAI (SWALL:P57553) (361 aa) fasta scores: E(): 4.4e-34, 42.22 [...]
 
 
 0.997
dnaQ
DNA polymerase III, epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
 
 0.996
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 0.995
HolA
Similar to Escherichia coli DNA polymerase III, delta subunit HolA or b0640 SWALL:HOLA_ECOLI (SWALL:P28630) (343 aa) fasta scores: E(): 2.1e-30, 33.96% id in 318 aa, and to Ralstonia solanacearum probable DNA polymerase III rsc2742 or rs00112 SWALL:Q8XVT5 (EMBL:AL646071) (358 aa) fasta scores: E(): 8.4e-85, 64.7% id in 357 aa.
 
 
 0.994
dnaE
Similar to Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SWALL:DP3A_ECOLI (SWALL:P10443) (1160 aa) fasta scores: E(): 1.2e-188, 49.2% id in 1197 aa, and to Ralstonia solanacearum probable DNA polymerase III rsc2205 or rs01394 SWALL:Q8XXB1 (EMBL:AL646068) (1173 aa) fasta scores: E(): 0, 73.06% id in 1203 aa.
  
 
 0.991
BPSL2556
Possible DNA polymerase/helicase; Similar to Bacillus halodurans DNA polymerase III PolC-type PolC or bh2418 SWALL:DPO3_BACHD (SWALL:Q9KA72) (1433 aa) fasta scores: E(): 1.1e-12, 35.54% id in 166 aa, and to Neisseria meningitidis DNA polymerase III, epsilon subunit nmb1451 SWALL:Q9JYS6 (EMBL:AE002495) (470 aa) fasta scores: E(): 2.2e-27, 42.35% id in 229 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog dinG SWALL:DING_BACSU (SWALL:P54394) (931 aa) fasta scores: E(): 7.6e-14, 38.79% id in 183 aa.
  
 0.985
BPSS2211
Similar to Pseudomonas aeruginosa probable ATP-dependent DNA ligase pa2138 SWALL:Q9I1X7 (EMBL:AE004641) (840 aa) fasta scores: E(): 3.9e-54, 42.03% id in 1123 aa, and to Xanthomonas campestris ATP-dependent DNA ligase xcc0105 SWALL:Q8PE76 (EMBL:AE012104) (1001 aa) fasta scores: E(): 4.3e-34, 35.13% id in 1147 aa. Note: There are some fragments in this CDS that present no similarities to any of the database matches.
   
 0.985
mutS
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
  
 0.978
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.