STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (533 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
 
 
 0.995
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.948
BPSL3405
Similar to Ralstonia solanacearum putative chromosome partitioning protein ParB or Rsc3325 or Rs02555 SWALL:Q8XU68 (EMBL:AL646074) (303 aa) fasta scores: E(): 2.3e-72, 73.12% id in 294 aa, and to Caulobacter crescentus chromosome partitioning protein ParB or Cc3752 SWALL:PARB_CAUCR (SWALL:O05190) (294 aa) fasta scores: E(): 3.8e-32, 42.42% id in 297 aa; Belongs to the ParB family.
 
  
 0.841
BPSS1680
Putative histone-like protein; Similar to Bordetella pertussis Bph2 SWALL:P94344 (EMBL:U82555) (145 aa) fasta scores: E(): 3.7e-26, 65.27% id in 144 aa, and to Xylella fastidiosa histone-like protein xf1943 SWALL:Q9PC42 (EMBL:AE004013) (130 aa) fasta scores: E(): 1.2e-18, 54.61% id in 130 aa; Belongs to the bacterial histone-like protein family.
    
 
 0.816
recR
Recombination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
  
 0.769
dnaX
DNA polymerase III subunit gamma; Similar to the N-terminal region of Escherichia coli DNA polymerase III subunit tau DnaX or DnaZ or DnaZX or b0470 SWALL:DP3X_ECOLI (SWALL:P06710) (643 aa) fasta scores: E(): 1.4e-51, 46.7% id in 531 aa, and to the N-terminal region of Ralstonia solanacearum probable DNA polymerase III rsc1191 or rs05723 SWALL:Q8Y053 (EMBL:AL646063) (728 aa) fasta scores: E(): 9e-82, 54.42% id in 836 aa, and to the full length of Buchnera aphidicola DNA polymerase III subunit gamma DnaX or bu481 SWALL:DP3X_BUCAI (SWALL:P57553) (361 aa) fasta scores: E(): 4.4e-34, 42.22 [...]
 
  
 0.716
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
  
 0.699
gmhA
Putative sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
    
 
 0.682
ruvA
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
  
 0.682
BPSL3273
Putative phosphosugar isomerase; Similar to Pseudomonas aeruginosa probable phosphoheptose isomerase Pa4425 SWALL:Q9HVZ0 (EMBL:AE004857) (197 aa) fasta scores: E(): 3.4e-25, 45.55% id in 191 aa, and to Burkholderia pseudomallei GmhA SWALL:Q93UJ2 (EMBL:AF228583) (197 aa) fasta scores: E(): 6.5e-15, 35.97% id in 189 aa, and to Aneurinibacillus thermoaerophilus sedoheptulose 7-phosphate isomerase GmhA SWALL:Q9AGY7 (EMBL:AF324836) (198 aa) fasta scores: E(): 2.2e-13, 35.75% id in 193 aa.
    
 
 0.682
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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