STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPSL0371Similar to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 1.5e-65, 48.84% id in 389 aa, and to Ralstonia solanacearum probable acetyl-CoA acetyltransferase rsc0276 or rs03243 SWALL:Q8Y2Q9 (EMBL:AL646058) (393 aa) fasta scores: E(): 6.7e-109, 74.42% id in 391 aa. Similar to BPSL1535, 50.643% identity (51.036% ungapped) in 389 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)    
Predicted Functional Partners:
BPSL0649
Similar to Ralstonia solanacearum putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein rsc0474 or rs04421 SWALL:Q8Y262 (EMBL:AL646059) (827 aa) fasta scores: E(): 0, 77.28% id in 810 aa. N-terminal region and to Homo sapiens short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor HADHSC or SCHAD SWALL:HCDH_HUMAN (SWALL:Q16836) (314 aa) fasta scores: E(): 1.6e-20, 34.57% id in 295 aa. R. solanacearum protein is extended at the N-terminus in comparison to CDS.
 
 0.996
BPSL0063
Similar to Pseudomonas fragi fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3- hydroxybutyryl-CoA epimerase] FaoA SWALL:FAOB_PSEFR (SWALL:P28793) (715 aa) fasta scores: E(): 5e-65, 36.06% id in 721 aa, and to Caulobacter crescentus fatty oxidation complex, alpha subunit CC0076 SWALL:Q9ABZ4 (EMBL:AE005681) (709 aa) fasta scores: E(): 8.9e-130, 55.26% id in 684 aa.
 
 0.995
BPSL1424
Putative fatty acid degradation protein (possibly trifunctional); Similar to Ralstonia solanacearum probable trifunctional: enoyl-CoA hydratase and delta3-cis-delta2-trans-enoyl-CoA isomerase and 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein rsc1759 or rs02946 SWALL:Q8XYJ9 (EMBL:AL646066) (706 aa) fasta scores: E(): 2.4e-192, 74.6% id in 693 aa, and to Escherichia coli fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase] FadB or OldB or b3846 SWALL [...]
 0.995
BPSL0419
Similar to Cavia porcellus peroxisomal bifunctional enzyme [includes: enoyl-CoA hydratase; 3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase] EHHADH SWALL:ECHP_CAVPO (SWALL:P55100) (725 aa) fasta scores: E(): 2.1e-66, 40.82% id in 703 aa, and to Rhizobium loti enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase mll4199 SWALL:Q98EK7 (EMBL:AP003003) (689 aa) fasta scores: E(): 1.1e-111, 50.14% id in 698 aa.
 
 0.954
BPSS1955
Putative phosphate acetyltransferase/enoyl-CoA hydratase fusion protein; N-terminal region similar to Pseudomonas aeruginosa (R)-specific enoyl-CoA hydratase PhaJ1 or pa3302 SWALL:Q9LBK2 (EMBL:AB040025) (156 aa) fasta scores: E(): 1.1e-17, 44.44% id in 153 aa, and C-terminal region to Rhizobium meliloti phosphate acetyltransferase Pta SWALL:PTA_RHIME (SWALL:Q9X448) (316 aa) fasta scores: E(): 5.4e-55, 57.37% id in 305 aa.
  
 0.946
BPSL1380
Putative acetyl-CoA synthetase; Similar to Bacillus subtilis acetyl-coenzyme A synthetase AcsA SWALL:ACSA_BACSU (SWALL:P39062) (572 aa) fasta scores: E(): 5.7e-54, 34.63% id in 540 aa, and to Rhizobium loti acetyl-CoA synthetase mll6017 SWALL:Q98AG0 (EMBL:AP003008) (562 aa) fasta scores: E(): 8.3e-119, 55.51% id in 553 aa.
  
 
 0.931
acoE
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.931
BPSS0618
AMP-binding enzyme; Similar to Ralstonia solanacearum probable acetyl-coenzyme A synthetase rsp0651 or rs05571 SWALL:Q8XS30 (EMBL:AL646080) (567 aa) fasta scores: E(): 2.8e-165, 75.22% id in 561 aa, and to Streptomyces coelicolor putative acetyl-coenzyme A synthetase SCO6195 or SC2G5.16 SWALL:Q9Z5A7 (EMBL:AL939126) (558 aa) fasta scores: E(): 1.1e-118, 58.46% id in 561 aa.
  
 
 0.931
aceB
Similar to Escherichia coli malate synthase A AceB or Mas or b4014 SWALL:MASY_ECOLI (SWALL:P08997) (533 aa) fasta scores: E(): 1.9e-103, 50.84% id in 533 aa, and to Ralstonia solanacearum probable malate synthase A rsc1363 or rs04645 SWALL:Q8XZN2 (EMBL:AL646064) (529 aa) fasta scores: E(): 1.5e-177, 79.84% id in 531 aa.
   
 
 0.927
BPSL0333
Similar to Homo sapiens hydroxymethylglutaryl-CoA lyase, mitochondrial precursor HMGCL SWALL:HMGL_HUMAN (SWALL:P35914) (325 aa) fasta scores: E(): 3.2e-58, 55.1% id in 294 aa, and to Ralstonia solanacearum putative hydroxymethylglutaryl-CoA lyase protein rsc0261 or rs00696 SWALL:Q8Y2S4 (EMBL:AL646058) (309 aa) fasta scores: E(): 3.2e-85, 78.59% id in 299 aa. CDS is truncated at the N-terminus in comparison to the other proteins, including the human hydroxymethylglutaryl-CoA lyase.
  
 
 0.925
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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