STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)    
Predicted Functional Partners:
lipB
Putative lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.930
BPSL2299
Putative dihydrolipoamide dehydrogenase; C-terminal region is similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 dihydrolipoamide dehydrogenase LpdA or Lpd SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.9e-93, 65.75% id in 473 aa. Full length CDS is similar to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1603 or rs03965 SWALL:Q8XZ03 (EMBL:AL646065) (594 aa) fasta scores: E(): 2.1e-142, 76.88% id in 597 aa.
 
  
 0.790
odhL
Similar to Alcaligenes eutrophus dihydrolipoamide dehydrogenase OdhL SWALL:DLDH_ALCEU (SWALL:P52992) (474 aa) fasta scores: E(): 9.7e-132, 76.93% id in 477 aa, and to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1271 or rs02809 SWALL:Q8XZX4 (EMBL:AL646063) (478 aa) fasta scores: E(): 2.9e-134, 77.35% id in 477 aa.
 
  
 0.764
lpdV
Similar to Pseudomonas putida dihydrolipoamide dehydrogenase LpdV SWALL:DLD1_PSEPU (SWALL:P09063) (459 aa) fasta scores: E(): 9.9e-115, 69.09% id in 466 aa, and to Pseudomonas aeruginosa lipoamide dehydrogenase-Val pa2250 SWALL:Q9I1L9 (EMBL:AE004650) (464 aa) fasta scores: E(): 2.6e-123, 71.24% id in 466 aa.
 
  
 0.764
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
      
 0.735
ndh
Similar to Escherichia coli NADH dehydrogenase Ndh or b1109 SWALL:DHNA_ECOLI (SWALL:P00393) (433 aa) fasta scores: E(): 9.1e-23, 45.43% id in 460 aa, and to Ralstonia solanacearum probable NADH dehydrogenase, membrane flavoprotein FAD NAD ubiquinone electron transport oxidoreductase Ndh or rsc2229 or rs01370 SWALL:Q8XX87 (EMBL:AL646069) (441 aa) fasta scores: E(): 3.1e-68, 62.66% id in 458 aa.
      
 0.714
narK
Similar to Escherichia coli nitrite extrusion protein 1 NarK SWALL:NARK_ECOLI (SWALL:P10903) (463 aa) fasta scores: E(): 4.3e-94, 54.6% id in 456 aa, and to Ralstonia solanacearum probable nitrite/nitrate transporter transmembrane protein rsp0973 or rs02305 SWALL:Q8XR86 (EMBL:AL646082) (461 aa) fasta scores: E(): 8.2e-147, 79.17% id in 461 aa.
      
 0.686
narK-2
Similar to Paracoccus pantotrophus nitrate/nitrite transporter NarK SWALL:Q93PW1 (EMBL:AF295359) (905 aa) fasta scores: E(): 4.5e-63, 41.2% id in 415 aa, and to Pseudomonas fluorescens putative nitrate/nitrite transporter narD SWALL:Q9F0X9 (EMBL:AF197465) (421 aa) fasta scores: E(): 1.6e-89, 56.46% id in 402 aa, and to Ralstonia solanacearum putative nitrite/nitrate transporter transmembrane protein NarK1 or rsp0972 or rs02304 SWALL:Q8XR87 (EMBL:AL646082) (437 aa) fasta scores: E(): 4.3e-85, 53.44% id in 421 aa, and to Pseudomonas aeruginosa nitrate extrusion protein NarK1 or pa3877 SW [...]
      
 0.686
sucB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
  
 0.646
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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