STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ubiCConserved hypothetical protein; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (197 aa)    
Predicted Functional Partners:
ubiA
Putative 4-hydroxybenzoate transmembrane octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
    
 0.940
pchA
Similar to Pseudomonas aeruginosa salicylate biosynthesis isochorismate synthase PchA SWALL:PCHA_PSEAE (SWALL:Q51508) (476 aa) fasta scores: E(): 1.4e-71, 48.94% id in 472 aa, and to Bacillus subtilis menaquinone-specific isochorismate synthase MenF or IcsM SWALL:MENF_BACSU (SWALL:P23973) (471 aa) fasta scores: E(): 7.2e-42, 32.25% id in 462 aa.
     
 0.915
pheA
Similar to many involved in Phenylalanine biosynthesis: Neisseria gonorrhoeae P-protein [includes: chorismate mutase (EC 5.4.99.5) (cm); prephenate dehydratase (EC 4.2.1.51) (pdt)] PheA SWALL:PHEA_NEIGO (SWALL:Q9ZHY3) (362 aa) fasta scores: E(): 1.8e-64, 50% id in 362 aa, Ralstonia solanacearum probable bifunctional protein: chorismate mutase and prephenate dehydratase PheA or rsc0904 or rs04511 SWALL:Q8Y0Y9 (EMBL:AL646061) (371 aa) fasta scores: E(): 9.6e-85, 61.45% id in 358 aa and to Pseudomonas stutzeri p-protein PheA SWALL:PHEA_PSEST (SWALL:P27603) (365 aa) fasta scores: E(): 3.4e [...]
    
 0.878
BPSL2555
Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate.
 
  
 0.845
hisC1
Similar to Lactococcus lactis histidinol-phosphate aminotransferase HisC SWALL:HIS8_LACLA (SWALL:Q02135) (360 aa) fasta scores: E(): 1.3e-55, 46.57% id in 350 aa, and to Rhizobium meliloti histidinol-phosphate aminotransferase 2 r03268 or smc03885 SWALL:HI82_RHIME (SWALL:Q92L21) (351 aa) fasta scores: E(): 2e-76, 61.01% id in 354 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
  0.844
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
    
 0.841
trpG
Similar to Pseudomonas aeruginosa anthranilate synthase component II TrpG or Pa0649 SWALL:TRPG_PSEAE (SWALL:P20576) (201 aa) fasta scores: E(): 2.3e-46, 64.58% id in 192 aa.
    
 0.813
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.3e-80, 54.63% id in 399 aa, and to Pseudomonas aeruginosa aspartate aminotransferase AspC or pa3139 SWALL:AAT_PSEAE (SWALL:P72173) (398 aa) fasta scores: E(): 2.6e-111, 73.86% id in 398 aa. Note: Also similar to BPSS0808 (401 aa) fasta scores: E(): 7.1e-72, 53.149% identity in 397 aa overlap.
     
 0.802
tyrB1
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 2.1e-90, 58.43% id in 397 aa, and to Klebsiella pneumoniae tyrosine aminotransferase TyrB SWALL:O85746 (EMBL:AF074934) (397 aa) fasta scores: E(): 2.8e-89, 57.17% id in 397 aa. Similar to BPSS2200, 55.556% identity in 396 aa overlap, and to BPSS0355, 53.149% identity in 397 aa overlap. Note: Also similar to BPSS2200 TyrB2 (405 aa)fasta scores: E(): 4.4e-79, 55.556% identity in 396 aa overlap;. Note: Also similar to BPSS2200 (444 aa) fasta scores: E(): 4.4e-7 [...]
     
 0.802
tyrB2
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 7.1e-92, 58.69% id in 397 aa, and to Pseudomonas putida aromatic-amino-acid aminotransferase TyrB-2 or pp3590 SWALL:AAN69190 (EMBL:AE016787) (398 aa) fasta scores: E(): 3.5e-91, 58.54% id in 398 aa. Note: Also similar to BPSS0808 TyrB1 (401 aa) fasta scores: E(): 1.1e-74, 55.556% identity in 396 aa overlap.
     
 0.802
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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