STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (130 aa)    
Predicted Functional Partners:
BPSS1259
Putative iron-containing alcohol dehydrogenase; Similar to Clostridium acetobutylicum NADH-dependent butanol dehydrogenase B BdhB or cac3298 SWALL:ADHB_CLOAB (SWALL:Q04945) (390 aa) fasta scores: E(): 1.1e-46, 39.72% id in 360 aa, and to Zymomonas mobilis NADH-dependent butanol dehydrogenase YugJ SWALL:Q9Z659 (EMBL:AF102543) (385 aa) fasta scores: E(): 2.8e-101, 67.79% id in 385 aa, and to Salmonella typhi probable alcohol dehydrogenase sty3337 SWALL:Q8Z3Q2 (EMBL:AL627277) (387 aa) fasta scores: E(): 3.2e-95, 63.99% id in 386 aa.
  
 
 0.917
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
  
    0.774
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
  
 0.745
pcnB
Putative polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.745
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
    0.707
BPSL1539
Putative fructokinase-like protein; Similar to Klebsiella pneumoniae fructokinase ScrK SWALL:SCRK_KLEPN (SWALL:P26420) (307 aa) fasta scores: E(): 4.2e-19, 31.49% id in 308 aa, and to Pseudomonas putida putative fructokinase-like protein ORF5 SWALL:BAB96556 (EMBL:AB085816) (307 aa) fasta scores: E(): 5.3e-90, 78.07% id in 301 aa.
   
 0.563
BPSS2247
Hypothetical protein; No significant database matches.
  
  
 0.468
BPSL0398
Putative biotin ligase; Similar to the C-terminal region of Escherichia coli birA bifunctional protein [includes: biotin operon repressor; biotin--(acetyl-CoA-carboxylase) synthetase] BirA or BioR or DhbB SWALL:BIRA_ECOLI (SWALL:P06709) (321 aa) fasta scores: E(): 0.31, 32.86% id in 283 aa, and to the full length Bordetella pertussis putative biotin protein ligase BirA SWALL:Q9ZIU6 (EMBL:AF016461) (288 aa) fasta scores: E(): 2.4e-06, 33.64% id in 324 aa.
  
  
 0.454
BPSL1167
Putative dehydrogenase; Similar to Xanthomonas axonopodis pv. citri str. 306 oxidoreductase xac0384 SWALL:AAM35276 (EMBL:AE011664) (260 aa) fasta scores: E(): 1.7e-66, 71.53% id in 260 aa, and to Ralstonia solanacearum probable dehydrogenase/reductase oxidoreductase protein rsc2186 or rs01413 SWALL:Q8XXC9 (EMBL:AL646068) (263 aa) fasta scores: E(): 3e-61, 67.3% id in 263 aa.
       0.446
pyrF
Similar to Ralstonia solanacearum orotidine 5'-phosphate decarboxylase rs00074 or rsc2773 SWALL:PYRF_RALSO (SWALL:P58642) (271 aa) fasta scores: E(): 1.5e-71, 72.86% id in 269 aa, and to Thermus thermophilus orotidine 5'-phosphate decarboxylase PyrF SWALL:PYRF_THETH (SWALL:P96076) (241 aa) fasta scores: E(): 8.9e-21, 39.35% id in 249 aa. Note: This CDS is longer in its N-terminal region than most of its database matches; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
   
 0.400
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.