STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (621 aa)    
Predicted Functional Partners:
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.951
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
 
  
 0.946
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.926
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.922
pykA
Putative pyruvate kinase II protein; Similar to Pseudomonas hydrogenothermophila pyruvate kinase Pyk SWALL:Q9LBF0 (EMBL:AB042618) (473 aa) fasta scores: E(): 5.5e-91, 58.82% id in 476 aa, and to Ralstonia solanacearum probable pyruvate kinase II protein rsc0572 or rs04893 SWALL:Q8Y1W5 (EMBL:AL646060) (479 aa) fasta scores: E(): 2.9e-131, 78.49% id in 479 aa.
  
 
 0.919
pyk
Pyruvate kinase; Similar to Bacillus stearothermophilus pyruvate kinase Pyk SWALL:KPYK_BACST (SWALL:Q02499) (587 aa) fasta scores: E(): 1.7e-60, 41.27% id in 470 aa, and to Pseudomonas aeruginosa pyruvate kinase I PykF or pa1498 SWALL:Q9I3L4 (EMBL:AE004578) (477 aa) fasta scores: E(): 1.5e-83, 55.57% id in 466 aa.
  
 
 0.919
BPSL0890
Putative citrate synthase; C-terminal region is similar to Agrobacterium tumefaciens citrate synthase CisZ or atu4851 or agr_l_71 SWALL:Q8U6F6 (EMBL:AE009414) (335 aa) fasta scores: E(): 6.7e-14, 42.68% id in 335 aa, and to Staphylococcus aureus citrate synthase II CitZ SWALL:Q99TG7 (EMBL:AP003363) (373 aa) fasta scores: E(): 4.7e-13, 27.36% id in 391 aa. Possible alternative translational start site.
     
 0.914
gltA
Citrate synthase; Similar to Rhizobium meliloti citrate synthase GltA or r01509 or smc02087 SWALL:CISY_RHIME (SWALL:O33915) (429 aa) fasta scores: E(): 1.4e-128, 70.23% id in 430 aa, and to Ralstonia solanacearum probable citrate synthase protein rsc1991 or rs03559 SWALL:Q8XXX2 (EMBL:AL646067) (433 aa) fasta scores: E(): 6.9e-149, 82.44% id in 433 aa.
     
 0.914
aceB
Similar to Escherichia coli malate synthase A AceB or Mas or b4014 SWALL:MASY_ECOLI (SWALL:P08997) (533 aa) fasta scores: E(): 1.9e-103, 50.84% id in 533 aa, and to Ralstonia solanacearum probable malate synthase A rsc1363 or rs04645 SWALL:Q8XZN2 (EMBL:AL646064) (529 aa) fasta scores: E(): 1.5e-177, 79.84% id in 531 aa.
     
 0.845
BPSL2925
Putative glutamate dehydrogenase; Similar to Bacillus subtilis NAD-specific glutamate dehydrogenase GudB SWALL:GUDB_BACSU (SWALL:P50735) (426 aa) fasta scores: E(): 2.1e-70, 47.51% id in 402 aa, and to Salmonella typhimurium putative homolog of glutamic dehyrogenase stm1795 SWALL:Q8ZP21 (EMBL:AE008780) (441 aa) fasta scores: E(): 2.4e-109, 64.67% id in 419 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.839
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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