STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucA2-oxoglutarate dehydrogenase E1 component; Similar to Escherichia coli, and Escherichia coli O157:H7 2-oxoglutarate dehydrogenase E1 component SucA or b0726 or z0880 or ecs0751 SWALL:ODO1_ECOLI (SWALL:P07015) (933 aa) fasta scores: E(): 1.8e-205, 55.07% id in 946 aa, and to Alcaligenes eutrophus 2-oxoglutarate dehydrogenase E1 component OdhA SWALL:ODO1_ALCEU (SWALL:Q59106) (950 aa) fasta scores: E(): 0, 77.39% id in 951 aa. (954 aa)    
Predicted Functional Partners:
sucB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
BPSL2299
Putative dihydrolipoamide dehydrogenase; C-terminal region is similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 dihydrolipoamide dehydrogenase LpdA or Lpd SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.9e-93, 65.75% id in 473 aa. Full length CDS is similar to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1603 or rs03965 SWALL:Q8XZ03 (EMBL:AL646065) (594 aa) fasta scores: E(): 2.1e-142, 76.88% id in 597 aa.
 
 0.999
odhL
Similar to Alcaligenes eutrophus dihydrolipoamide dehydrogenase OdhL SWALL:DLDH_ALCEU (SWALL:P52992) (474 aa) fasta scores: E(): 9.7e-132, 76.93% id in 477 aa, and to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1271 or rs02809 SWALL:Q8XZX4 (EMBL:AL646063) (478 aa) fasta scores: E(): 2.9e-134, 77.35% id in 477 aa.
 
 0.995
lpdV
Similar to Pseudomonas putida dihydrolipoamide dehydrogenase LpdV SWALL:DLD1_PSEPU (SWALL:P09063) (459 aa) fasta scores: E(): 9.9e-115, 69.09% id in 466 aa, and to Pseudomonas aeruginosa lipoamide dehydrogenase-Val pa2250 SWALL:Q9I1L9 (EMBL:AE004650) (464 aa) fasta scores: E(): 2.6e-123, 71.24% id in 466 aa.
 
 0.991
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.987
pdhB
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.982
sucD
succinyl-CoA ligase alpha-chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.978
bkdB
Similar to Pseudomonas putida lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex BkdB SWALL:ODB2_PSEPU (SWALL:P09062) (423 aa) fasta scores: E(): 2e-70, 61.15% id in 484 aa, and to Pseudomonas aeruginosa branched-chain alpha-keto acid dehydrogenase pa2249 SWALL:Q9I1M0 (EMBL:AE004650) (428 aa) fasta scores: E(): 1.5e-74, 62.68% id in 485 aa. CDS contains additional amino acids relative to some orthologues.
 0.978
icd
Similar to Alcaligenes eutrophus isocitrate dehydrogenase isozyme 1 Icd1 SWALL:CAD32550 (EMBL:AJ488288) (442 aa) fasta scores: E(): 5.7e-133, 85.81% id in 416 aa, and to Ralstonia solanacearum probable isocitrate dehydrogenase Icd or rsc2490 or rs01106 SWALL:Q8XWI4 (EMBL:AL646070) (416 aa) fasta scores: E(): 2.5e-139, 88.7% id in 416 aa.
   
 
 0.974
sdhA
Succinate dehydrogenase flavoprotein subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 succinate dehydrogenase flavoprotein subunit SdhA or b0723 or c0801 or z0877 or ecs0748 SWALL:DHSA_ECOLI (SWALL:P10444) (588 aa) fasta scores: E(): 7.9e-127, 55.46% id in 586 aa, and to Ralstonia solanacearum putative succinate dehydrogenase SdhA or rsc1994 or rs03562 SWALL:Q8XXW9 (EMBL:AL646067) (592 aa) fasta scores: E(): 6.1e-201, 85.3% id in 592 aa; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 
 0.943
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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