STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
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[Homology]
Score
glnDPutative uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (858 aa)    
Predicted Functional Partners:
glnB2
Nitrogen regulatory protein P-II 2; Similar to Escherichia coli, Escherichia coli O157:H7, Salmonella typhimurium, and Salmonella typhi nitrogen regulatory protein P-II 1 GlnB or b2553 or z3829 or ecs3419 or stm2561 or sty2808 SWALL:GLNB_ECOLI (SWALL:P05826) (112 aa) fasta scores: E(): 3.1e-30, 77.67% id in 112 aa, and to Ralstonia solanacearum probable nitrogen regulatory P-II transcription regulator protein rsc2345 or rs01201 SWALL:Q8XWX5 (EMBL:AL646069) (112 aa) fasta scores: E(): 6.7e-32, 83.92% id in 112 aa; Belongs to the P(II) protein family.
 
 
 0.984
glnB1
Similar to Klebsiella pneumoniae nitrogen regulatory protein P-II GlnB SWALL:GLNB_KLEPN (SWALL:P11671) (112 aa) fasta scores: E(): 2.2e-26, 70.53% id in 112 aa, and to Ralstonia solanacearum probable nitrogen regulatory P-II transcription regulator protein rsc0342 or rs06099 SWALL:Q8Y2J3 (EMBL:AL646058) (112 aa) fasta scores: E(): 1.1e-32, 84.82% id in 112 aa. Similar to BPSL1027, 75.000% identity (75.000% ungapped) in 112 aa overlap; Belongs to the P(II) protein family.
 
 
 
 0.858
glnE
Putative glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the sign [...]
 
   
 0.801
xerD
Putative integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
  
  
 0.608
glt1
Glutamate synthase large subunit; Similar to Synechocystis sp. ferredoxin-dependent glutamate synthase 2 GltS or Sll1499 SWALL:GLTS_SYNY3 (SWALL:P55038) (1556 aa) fasta scores: E(): 0, 43.8% id in 1573 aa, and to Ralstonia solanacearum probable glutamate synthase GltB or Rsc2965 or Rs01332 SWALL:Q8XV66 (EMBL:AL646072) (1582 aa) fasta scores: E(): 0, 83.76% id in 1564 aa.
     
 0.560
glnA
Similar to Escherichia coli glutamine synthetase GlnA SWALL:GLNA_ECOLI (SWALL:P06711) (468 aa) fasta scores: E(): 3.4e-133, 65.51% id in 464 aa, and to Ralstonia solanacearum probable glutamine synthetase protein rsc1258 or rs02774 SWALL:Q8XZY7 (EMBL:AL646063) (471 aa) fasta scores: E(): 2e-175, 85.77% id in 471 aa.
 
   
 0.554
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.550
glnL
Similar to Escherichia coli, and Escherichia coli O157:H7 nitrogen regulation protein NR(II) GlnL or NtrB or GlnR SWALL:NTRB_ECOLI (SWALL:P06712) (349 aa) fasta scores: E(): 1e-35, 42.45% id in 351 aa, and to Ralstonia solanacearum probable nitrogen regulation rsc1260 or rs02784 SWALL:Q8XZY5 (EMBL:AL646063) (361 aa) fasta scores: E(): 8.6e-86, 68.96% id in 348 aa.
  
 
 
 0.550
bamA
Putative outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.529
rpoN
Putative RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
      
 0.510
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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