STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (227 aa)    
Predicted Functional Partners:
rpoZ
DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.979
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.969
apt
Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.968
spoT
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.960
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.946
BPSL2996
Similar to Bacillus subtilis hypoxanthine-guanine phosphoribosyltransferase HprT or Hpt SWALL:HPRT_BACSU (SWALL:P37472) (180 aa) fasta scores: E(): 2.5e-12, 29.94% id in 177 aa, and to Ralstonia solanacearum probable hypoxanthine phosphoribosyltransferase transmembrane protein rsc2812 or rs00293 SWALL:Q8XVL8 (EMBL:AL646072) (182 aa) fasta scores: E(): 4.2e-52, 76.53% id in 179 aa.
  
  
 0.942
pyk
Pyruvate kinase; Similar to Bacillus stearothermophilus pyruvate kinase Pyk SWALL:KPYK_BACST (SWALL:Q02499) (587 aa) fasta scores: E(): 1.7e-60, 41.27% id in 470 aa, and to Pseudomonas aeruginosa pyruvate kinase I PykF or pa1498 SWALL:Q9I3L4 (EMBL:AE004578) (477 aa) fasta scores: E(): 1.5e-83, 55.57% id in 466 aa.
 
 
 0.934
pykA
Putative pyruvate kinase II protein; Similar to Pseudomonas hydrogenothermophila pyruvate kinase Pyk SWALL:Q9LBF0 (EMBL:AB042618) (473 aa) fasta scores: E(): 5.5e-91, 58.82% id in 476 aa, and to Ralstonia solanacearum probable pyruvate kinase II protein rsc0572 or rs04893 SWALL:Q8Y1W5 (EMBL:AL646060) (479 aa) fasta scores: E(): 2.9e-131, 78.49% id in 479 aa.
 
 
 0.932
BPSL2973
Putative exported protein; No significant database matches.
    
 0.924
BPSL2564
Conserved hypothetical protein; Similar to many proteins of undefined function including: Ralstonia solanacearum hypothetical protein rsc2156 or rs01446 SWALL:Q8XXF8 (EMBL:AL646068) (311 aa) fasta scores: E(): 4.6e-64, 64.42% id in 312 aa, and to Haemophilus influenzae protein Hi0467 SWALL:YICC_HAEIN (SWALL:P44726) (287 aa) fasta scores: E(): 6.6e-13, 33.22% id in 307 aa.
  
  
 0.923
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.