STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLSimilar to Neisseria meningitidis glutamate-1-semialdehyde 2,1-aminomutase HemL or nmb1864 SWALL:GSA_NEIMB (SWALL:Q9JXW0) (427 aa) fasta scores: E(): 3.2e-104, 66.82% id in 425 aa, and to Ralstonia solanacearum probable glutamate-1-semialdehyde 2,1-aminomutase protein HemL or rsc0666 or rs01571 SWALL:Q8Y1M4 (EMBL:AL646060) (433 aa) fasta scores: E(): 7.7e-118, 76.69% id in 429 aa. (427 aa)    
Predicted Functional Partners:
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or Pa5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 2e-85, 70.3% id in 330 aa; Belongs to the ALAD family.
 
 
 0.989
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.985
BPSS2171
Putative aminotransferase; Similar to Pseudomonas aeruginosa probable aminotransferase pa5523 SWALL:Q9HT50 (EMBL:AE004964) (450 aa) fasta scores: E(): 1.3e-107, 61.76% id in 442 aa. C-terminus is similar to the C-terminal region of Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC SWALL:GSA_ECOLI (SWALL:P23893) (426 aa) fasta scores: E(): 3.3e-26, 31% id in 400 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.919
hemC
Putative porphobilinogen deaminase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.897
BPSS1181
Putative surfactin/non-ribosomally encoded peptide/polyketide synthase; Similar to Streptomyces pristinaespiralis pristinamycin I synthase I SnbC SWALL:Q54959 (EMBL:X98690) (2591 aa) fasta scores: E(): 6.9e-60, 41.81% id in 507 aa, and to Anabaena sp. hypothetical protein All1695 SWALL:Q8YWC0 (EMBL:AP003586) (1449 aa) fasta scores: E(): 4.5e-62, 41.42% id in 507 aa; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
 0.868
BPSS1170
Putative non-ribosomal peptide synthase/polyketide synthase; Similar to Polyangium cellulosum polyketide synthase EpoB SWALL:Q9L8C8 (EMBL:AF210843) (1832 aa) fasta scores: E(): 2.2e-74, 42.47% id in 664 aa, and to Polyangium cellulosum EpoC SWALL:Q9KIZ8 (EMBL:AF217189) (1832 aa) fasta scores: E(): 9.3e-74, 42.16% id in 664 aa, and to Nostoc sp. GSV224 NosB SWALL:Q9RAH3 (EMBL:AF204805) (1244 aa) fasta scores: E(): 9.1e-73, 45.99% id in 524 aa.
    
 0.864
ribD
Multifunctional riboflavin biosynthetic protein [deaminase, reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.757
ribE
Similar to Photobacterium phosphoreum riboflavin synthase alpha chain RibE SWALL:RISA_PHOPO (SWALL:P51961) (218 aa) fasta scores: E(): 3.9e-26, 45.77% id in 201 aa, and to Ralstonia solanacearum probable riboflavin synthase RibE or rsc0714 or rs05139 SWALL:Q8Y1H6 (EMBL:AL646060) (217 aa) fasta scores: E(): 1.8e-53, 75.37% id in 199 aa.
     
 0.720
BPSL1431
Similar to Alcaligenes eutrophus putative esterase/lipase SWALL:Q44019 (EMBL:L36817) (364 aa) fasta scores: E(): 4.5e-74, 60.62% id in 320 aa, and to Ralstonia solanacearum probable esterase/lipase protein rsc1772 or rs02959 SWALL:Q8XYI6 (EMBL:AL646066) (344 aa) fasta scores: E(): 6e-69, 57.72% id in 317 aa.
      
 0.704
BPSS1245
Similar to Pseudomonas fluorescens uroporphyrin-III c-methyltransferase CobA SWALL:SUMT_PSEFL (SWALL:P37725) (247 aa) fasta scores: E(): 2.2e-32, 46.38% id in 235 aa, and to Xanthomonas campestris uroporphyrin-III c-methyltransferase CysG or xcc2010 SWALL:AAM41299 (EMBL:AE012305) (258 aa) fasta scores: E(): 1.5e-49, 63.55% id in 236 aa, and to Pseudomonas aeruginosa uroporphyrin-III c-methyltransferase CobA or pa1778 SWALL:Q9I2W4 (EMBL:AE004603) (245 aa) fasta scores: E(): 5e-37, 51.31% id in 228 aa; possible alternative start site at codon 41 and codon 44.
 
   
 0.698
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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