STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
nadKPutative ATP-NAD kinase/inorganic polyphosphatase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (300 aa)    
Predicted Functional Partners:
nadE-2
Putative glutamine-dependent NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.983
nadE
Putative NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.968
nadD
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.942
pntAB
NAD(P) transhydrogenase subunit alpha; Similar to the C-terminal region of Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) PntA or b1603 SWALL:PNTA_ECOLI (SWALL:P07001) (510 aa) fasta scores: E(): 4.5e-12, 58.53% id in 82 aa, and to Ralstonia solanacearum probable transmembrane NAD(P) transhydrogenase subunit alpha rsc2732 or rs00122 SWALL:Q8XVU5 (EMBL:AL646071) (107 aa) fasta scores: E(): 9.1e-26, 80.61% id in 98 aa.
     
 0.921
pntAA
NAD(P) transhydrogenase subunit alpha; Similar to the N-terminal region of Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) PntA or b1603 SWALL:PNTA_ECOLI (SWALL:P07001) (510 aa) fasta scores: E(): 4.9e-42, 44.85% id in 379 aa, and to Ralstonia solanacearum probable NAD(P) transhydrogenase subunit alpha rsc2730 or rs00124 SWALL:Q8XVU7 (EMBL:AL646071) (379 aa) fasta scores: E(): 3.6e-92, 72.75% id in 378 aa.
     
 0.919
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.910
BPSL2834
Putative RecN DNA repair protein; May be involved in recombinational repair of damaged DNA.
 
  
 0.836
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
      
 0.713
surE
Acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.680
dxs
1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
    
 0.666
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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