node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | glyA-2 | BPSL2758 | BPSS0547 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
glyA | purA | BPSL2758 | BPSL1524 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.727 |
glyA | purB | BPSL2758 | BPSL2928 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 2.5e-109, 62.55% id in 454 aa, and to Ralstonia solanacearum probable adenylosuccinate lyase protein rsc2720 or rs00002 SWALL:Q8XVV7 (EMBL:AL646071) (457 aa) fasta scores: E(): 9.1e-148, 82.41% id in 455 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. It contains an alternative start codon at residue 22. | 0.684 |
glyA | purD | BPSL2758 | BPSL1164 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD or b4005 SWALL:PUR2_ECOLI (SWALL:P15640) (429 aa) fasta scores: E(): 1.5e-94, 60.42% id in 427 aa, and to Ralstonia solanacearum phosphoribosylamine--glycine ligase rsc2191 or rs01408 SWALL:PUR2_RALSO (SWALL:Q8XXC4) (422 aa) fasta scores: E(): 3.5e-122, 74.88% id in 422 aa; Belongs to the GARS family. | 0.596 |
glyA | purF | BPSL2758 | BPSS1692 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.736 |
glyA | purH | BPSL2758 | BPSL2896 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (aicar transformylase); IMP cyclohydrolase (EC 3.5.4.10) (inosinicase) (IMP synthetase) (atic)] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 1.5e-122, 62.28% id in 525 aa, and to Ralstonia solanacearum probable bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase transmembrane protein rsc0504 or rs05018 SWALL:Q8Y232 (EMBL:AL646059) (524 aa) fasta scores: E(): 4.6e-170 [...] | 0.983 |
glyA | purM | BPSL2758 | BPSL2818 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-78, 59.76% id in 343 aa, and to Ralstonia solanacearum probable phosphoribosylformylglycinamidine cyclo-ligase PurM or rsc2623 or rs00927 SWALL:Q8XW52 (EMBL:AL646071) (353 aa) fasta scores: E(): 1.9e-108, 81.21% id in 346 aa, and to Neisseria meningitidis putative phosphoribosylformylglycinamidine cyclo-ligase PurM or nma1421 SWALL:Q9JUA2 (EMBL:AL162755) (344 aa) fasta scores: E(): 7.4e-90, 68.73% id in 339 aa. | 0.627 |
glyA | purN | BPSL2758 | BPSL0908 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
glyA | purT | BPSL2758 | BPSL1111 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.910 |
glyA-2 | glyA | BPSS0547 | BPSL2758 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
glyA-2 | purA | BPSS0547 | BPSL1524 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.727 |
glyA-2 | purB | BPSS0547 | BPSL2928 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 2.5e-109, 62.55% id in 454 aa, and to Ralstonia solanacearum probable adenylosuccinate lyase protein rsc2720 or rs00002 SWALL:Q8XVV7 (EMBL:AL646071) (457 aa) fasta scores: E(): 9.1e-148, 82.41% id in 455 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. It contains an alternative start codon at residue 22. | 0.684 |
glyA-2 | purD | BPSS0547 | BPSL1164 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD or b4005 SWALL:PUR2_ECOLI (SWALL:P15640) (429 aa) fasta scores: E(): 1.5e-94, 60.42% id in 427 aa, and to Ralstonia solanacearum phosphoribosylamine--glycine ligase rsc2191 or rs01408 SWALL:PUR2_RALSO (SWALL:Q8XXC4) (422 aa) fasta scores: E(): 3.5e-122, 74.88% id in 422 aa; Belongs to the GARS family. | 0.596 |
glyA-2 | purF | BPSS0547 | BPSS1692 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.736 |
glyA-2 | purH | BPSS0547 | BPSL2896 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (aicar transformylase); IMP cyclohydrolase (EC 3.5.4.10) (inosinicase) (IMP synthetase) (atic)] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 1.5e-122, 62.28% id in 525 aa, and to Ralstonia solanacearum probable bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase transmembrane protein rsc0504 or rs05018 SWALL:Q8Y232 (EMBL:AL646059) (524 aa) fasta scores: E(): 4.6e-170 [...] | 0.983 |
glyA-2 | purM | BPSS0547 | BPSL2818 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-78, 59.76% id in 343 aa, and to Ralstonia solanacearum probable phosphoribosylformylglycinamidine cyclo-ligase PurM or rsc2623 or rs00927 SWALL:Q8XW52 (EMBL:AL646071) (353 aa) fasta scores: E(): 1.9e-108, 81.21% id in 346 aa, and to Neisseria meningitidis putative phosphoribosylformylglycinamidine cyclo-ligase PurM or nma1421 SWALL:Q9JUA2 (EMBL:AL162755) (344 aa) fasta scores: E(): 7.4e-90, 68.73% id in 339 aa. | 0.627 |
glyA-2 | purN | BPSS0547 | BPSL0908 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
glyA-2 | purT | BPSS0547 | BPSL1111 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.910 |
purA | glyA | BPSL1524 | BPSL2758 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.727 |
purA | glyA-2 | BPSL1524 | BPSS0547 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.727 |