STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (441 aa)    
Predicted Functional Partners:
hemL
Similar to Neisseria meningitidis glutamate-1-semialdehyde 2,1-aminomutase HemL or nmb1864 SWALL:GSA_NEIMB (SWALL:Q9JXW0) (427 aa) fasta scores: E(): 3.2e-104, 66.82% id in 425 aa, and to Ralstonia solanacearum probable glutamate-1-semialdehyde 2,1-aminomutase protein HemL or rsc0666 or rs01571 SWALL:Q8Y1M4 (EMBL:AL646060) (433 aa) fasta scores: E(): 7.7e-118, 76.69% id in 429 aa.
 
 0.985
hemC
Putative porphobilinogen deaminase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.976
BPSS2171
Putative aminotransferase; Similar to Pseudomonas aeruginosa probable aminotransferase pa5523 SWALL:Q9HT50 (EMBL:AE004964) (450 aa) fasta scores: E(): 1.3e-107, 61.76% id in 442 aa. C-terminus is similar to the C-terminal region of Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC SWALL:GSA_ECOLI (SWALL:P23893) (426 aa) fasta scores: E(): 3.3e-26, 31% id in 400 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.955
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.930
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or Pa5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 2e-85, 70.3% id in 330 aa; Belongs to the ALAD family.
 
  
 0.868
BPSS1245
Similar to Pseudomonas fluorescens uroporphyrin-III c-methyltransferase CobA SWALL:SUMT_PSEFL (SWALL:P37725) (247 aa) fasta scores: E(): 2.2e-32, 46.38% id in 235 aa, and to Xanthomonas campestris uroporphyrin-III c-methyltransferase CysG or xcc2010 SWALL:AAM41299 (EMBL:AE012305) (258 aa) fasta scores: E(): 1.5e-49, 63.55% id in 236 aa, and to Pseudomonas aeruginosa uroporphyrin-III c-methyltransferase CobA or pa1778 SWALL:Q9I2W4 (EMBL:AE004603) (245 aa) fasta scores: E(): 5e-37, 51.31% id in 228 aa; possible alternative start site at codon 41 and codon 44.
 
  
 0.783
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.771
BPSL0961
Similar to Paracoccus denitrificans uroporphyrin-III C-methyltransferase NirE SWALL:NIRE_PARDE (SWALL:Q51701) (287 aa) fasta scores: E(): 1.3e-24, 43.75% id in 256 aa, and to the C-terminal region of Escherichia coli, and Escherichia coli O157:H7 siroheme synthase [includes: uroporphyrin-iii c-methyltransferase; precorrin-2 oxidase; ferrochelatase] CysG or b3368 or z4729 or ecs4219 SWALL:CYSG_ECOLI (SWALL:P11098) (457 aa) fasta scores: E(): 4.3e-23, 41.35% id in 237 aa.
 
  
 0.765
cobQ
Putative cobyric acid synthase protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
   
 0.737
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.677
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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