STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCSimilar to Streptomyces coelicolor histidinol-phosphate aminotransferase 1 HisC1 or HisC or SCO2053 or SC4G6.22c SWALL:HI81_STRCO (SWALL:P16246) (369 aa) fasta scores: E(): 9.9e-30, 36.63% id in 363 aa, and to Ralstonia solanacearum histidinol-phosphate aminotransferase 1 HisC1 or Rsc2951 or Rs00135 SWALL:HI81_RALSO (SWALL:Q8XV80) (374 aa) fasta scores: E(): 1.9e-87, 67.13% id in 353 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)    
Predicted Functional Partners:
hisB
Similar to Azospirillum brasilense imidazoleglycerol-phosphate dehydratase HisB SWALL:HIS7_AZOBR (SWALL:P18787) (207 aa) fasta scores: E(): 1.3e-40, 56.77% id in 192 aa, and to Escherichia coli histidine biosynthesis bifunctional protein Hisb [includes: histidinol-phosphatase (EC 3.1.3.15); imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IgpD)] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 8.2e-33, 49.48% id in 194 aa.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.995
pheA
Similar to many involved in Phenylalanine biosynthesis: Neisseria gonorrhoeae P-protein [includes: chorismate mutase (EC 5.4.99.5) (cm); prephenate dehydratase (EC 4.2.1.51) (pdt)] PheA SWALL:PHEA_NEIGO (SWALL:Q9ZHY3) (362 aa) fasta scores: E(): 1.8e-64, 50% id in 362 aa, Ralstonia solanacearum probable bifunctional protein: chorismate mutase and prephenate dehydratase PheA or rsc0904 or rs04511 SWALL:Q8Y0Y9 (EMBL:AL646061) (371 aa) fasta scores: E(): 9.6e-85, 61.45% id in 358 aa and to Pseudomonas stutzeri p-protein PheA SWALL:PHEA_PSEST (SWALL:P27603) (365 aa) fasta scores: E(): 3.4e [...]
 
 
 0.959
hisH
Imidazole glycerol phosphate synthase subunit hish; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.944
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.942
BPSS0339
Putative amino acid dioxygenase; Similar to Pseudomonas putida 4-hydroxyphenylpyruvate dioxygenase, putative pp2554 SWALL:AAN68163 (EMBL:AE016783) (635 aa) fasta scores: E(): 2.8e-61, 53.44% id in 683 aa. CDS contains region with additional internal amino acids (residues 272 to 338) in comparison to orthologues.
    
 0.924
BPSL1724
Similar to Anabaena sp. histidinol-phosphate aminotransferase 1 HisC1 or alr2092 SWALL:HI81_ANASP (SWALL:Q8YV89) (353 aa) fasta scores: E(): 3.1e-20, 31.17% id in 324 aa, and to Halobacterium volcanii histidinol-phosphate aminotransferase HisC SWALL:HIS8_HALVO (SWALL:P17736) (361 aa) fasta scores: E(): 7.6e-18, 30.74% id in 322 aa.
  
  
 
0.923
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.922
BPSL0409
Putative D-amino acid aminotransferase; Similar to Bacillus licheniformis D-alanine aminotransferase Dat SWALL:DAAA_BACLI (SWALL:P54692) (283 aa) fasta scores: E(): 8.7e-28, 40.42% id in 282 aa, and to Listeria innocua D-alanine aminotransferase lin1660 SWALL:DAAA_LISIN (SWALL:Q92B90) (289 aa) fasta scores: E(): 1.8e-27, 36.74% id in 283 aa.
  
 
 0.917
BPSS2310
Acetyltransferase (GNAT) family protein; Similar to Pseudomonas aeruginosa hypothetical protein pa1377 SWALL:Q9I3W7 (EMBL:AE004567) (177 aa) fasta scores: E(): 1.1e-13, 32.92% id in 164 aa, and to Salmonella typhimurium putative transferase stm3546 SWALL:Q8ZLG1 (EMBL:AE008863) (162 aa) fasta scores: E(): 5.9e-13, 35.36% id in 164 aa.
 
  
  0.913
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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