STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa)    
Predicted Functional Partners:
hisB
Similar to Azospirillum brasilense imidazoleglycerol-phosphate dehydratase HisB SWALL:HIS7_AZOBR (SWALL:P18787) (207 aa) fasta scores: E(): 1.3e-40, 56.77% id in 192 aa, and to Escherichia coli histidine biosynthesis bifunctional protein Hisb [includes: histidinol-phosphatase (EC 3.1.3.15); imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IgpD)] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 8.2e-33, 49.48% id in 194 aa.
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.997
hisC
Similar to Streptomyces coelicolor histidinol-phosphate aminotransferase 1 HisC1 or HisC or SCO2053 or SC4G6.22c SWALL:HI81_STRCO (SWALL:P16246) (369 aa) fasta scores: E(): 9.9e-30, 36.63% id in 363 aa, and to Ralstonia solanacearum histidinol-phosphate aminotransferase 1 HisC1 or Rsc2951 or Rs00135 SWALL:HI81_RALSO (SWALL:Q8XV80) (374 aa) fasta scores: E(): 1.9e-87, 67.13% id in 353 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.995
hisH
Imidazole glycerol phosphate synthase subunit hish; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.991
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.990
hisA
Similar to Azospirillum brasilense 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) HisA SWALL:HIS4_AZOBR (SWALL:P26720) (254 aa) fasta scores: E(): 9e-41, 53.64% id in 233 aa, and to Ralstonia solanacearum 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) HisA or Rsc2947 or Rs00139 SWALL:HIS4_RALSO (SWALL:Q8XV84) [...]
 
  
 0.990
hisE
Similar to Azospirillum brasilense phosphoribosyl-ATP pyrophosphatase HisE SWALL:HIS2_AZOBR (SWALL:P26722) (111 aa) fasta scores: E(): 2.9e-12, 48.07% id in 104 aa.
 
  
 0.987
hisC1
Similar to Lactococcus lactis histidinol-phosphate aminotransferase HisC SWALL:HIS8_LACLA (SWALL:Q02135) (360 aa) fasta scores: E(): 1.3e-55, 46.57% id in 350 aa, and to Rhizobium meliloti histidinol-phosphate aminotransferase 2 r03268 or smc03885 SWALL:HI82_RHIME (SWALL:Q92L21) (351 aa) fasta scores: E(): 2e-76, 61.01% id in 354 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.968
hisZ
Putative ATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 
  
 0.953
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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