STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.999
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 0.995
aroE-2
Similar to Corynebacterium glutamicum shikimate 5-dehydrogenase AroE or cgl0424 SWALL:AROE_CORGL (SWALL:Q9X5C9) (280 aa) fasta scores: E(): 8.9e-36, 48.39% id in 281 aa, and to Ralstonia solanacearum probable shikimate 5-dehydrogenase oxidoreductase protein rsp1398 or rs02060 SWALL:Q8XQ88 (EMBL:AL646084) (315 aa) fasta scores: E(): 3.2e-68, 72.92% id in 277 aa.
 
 0.993
aroA
Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.975
aroA/tyrA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.974
BPSL0684
Putative 3-phosphoskimimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 
 0.947
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.886
pheA
Similar to many involved in Phenylalanine biosynthesis: Neisseria gonorrhoeae P-protein [includes: chorismate mutase (EC 5.4.99.5) (cm); prephenate dehydratase (EC 4.2.1.51) (pdt)] PheA SWALL:PHEA_NEIGO (SWALL:Q9ZHY3) (362 aa) fasta scores: E(): 1.8e-64, 50% id in 362 aa, Ralstonia solanacearum probable bifunctional protein: chorismate mutase and prephenate dehydratase PheA or rsc0904 or rs04511 SWALL:Q8Y0Y9 (EMBL:AL646061) (371 aa) fasta scores: E(): 9.6e-85, 61.45% id in 358 aa and to Pseudomonas stutzeri p-protein PheA SWALL:PHEA_PSEST (SWALL:P27603) (365 aa) fasta scores: E(): 3.4e [...]
 
  
 0.789
trpG
Similar to Pseudomonas aeruginosa anthranilate synthase component II TrpG or Pa0649 SWALL:TRPG_PSEAE (SWALL:P20576) (201 aa) fasta scores: E(): 2.3e-46, 64.58% id in 192 aa.
 
   
 0.708
BPSL3170
Putative secretion system protein; Similar to regions from larger proteins eg. Ralstonia solanacearum probable fimbrial type-4 assembly signal peptide protein PilQ or Rsc2971 or Rs01326 SWALL:Q8XV60 (EMBL:AL646073) (714 aa) fasta scores: E(): 5.7e-36, 49.16% id in 421 aa, and to Haemophilus influenzae competence protein E precursor or hi0435 SWALL:COME_HAEIN (SWALL:P31772) (445 aa) fasta scores: E(): 4.7e-31, 31.64% id in 414 aa.
     
 0.705
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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