STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPGlycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)    
Predicted Functional Partners:
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.997
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.997
soxA
Similar to Corynebacterium sp. sarcosine oxidase alpha subunit SoxA SWALL:SOXA_CORS1 (SWALL:Q46337) (967 aa) fasta scores: E(): 2.3e-145, 46.45% id in 1014 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxA2 or rsc1103 or rs04054 SWALL:Q8Y0E1 (EMBL:AL646062) (1003 aa) fasta scores: E(): 0, 86.14% id in 1003 aa, and to Pseudomonas aeruginosa sarcosine oxidase alpha subunit SoxA or pa5418 SWALL:Q9HTE6 (EMBL:AE004954) (1005 aa) fasta scores: E(): 1.3e-211, 57.46% id in 1011 aa; Belongs to the GcvT family.
 
 0.997
BPSL2299
Putative dihydrolipoamide dehydrogenase; C-terminal region is similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 dihydrolipoamide dehydrogenase LpdA or Lpd SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.9e-93, 65.75% id in 473 aa. Full length CDS is similar to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1603 or rs03965 SWALL:Q8XZ03 (EMBL:AL646065) (594 aa) fasta scores: E(): 2.1e-142, 76.88% id in 597 aa.
 
 
 0.978
BPSL0053
Conserved hypothetical protein; Similar to Klebsiella aerogenes MoaF protein precursor SWALL:MOAF_KLEAE (SWALL:P54796) (262 aa) fasta scores: E(): 1.3e-16, 31.81% id in 242 aa, and to Pseudomonas aeruginosa hypothetical protein pa4087 SWALL:Q9HWU1 (EMBL:AE004825) (274 aa) fasta scores: E(): 1.2e-16, 31.95% id in 266 aa.
  
  
 0.964
purD
Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD or b4005 SWALL:PUR2_ECOLI (SWALL:P15640) (429 aa) fasta scores: E(): 1.5e-94, 60.42% id in 427 aa, and to Ralstonia solanacearum phosphoribosylamine--glycine ligase rsc2191 or rs01408 SWALL:PUR2_RALSO (SWALL:Q8XXC4) (422 aa) fasta scores: E(): 3.5e-122, 74.88% id in 422 aa; Belongs to the GARS family.
  
  
 0.964
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.964
BPSS0865
Conserved hypothetical protein; Similar to Klebsiella aerogenes MoaF protein precursor MoaF SWALL:MOAF_KLEAE (SWALL:P54796) (262 aa) fasta scores: E(): 6.4e-38, 46.83% id in 284 aa, and to Pseudomonas aeruginosa hypothetical protein pa4087 SWALL:Q9HWU1 (EMBL:AE004825) (274 aa) fasta scores: E(): 1.6e-39, 50% id in 282 aa.
  
  
 0.964
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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