STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (364 aa)    
Predicted Functional Partners:
BPSS1278
Putative membrane protein (fragment); Probable gene remnant. Similar to the C-terminal regions of Chromobacterium violaceum probable membrane transport protein SWALL:Q7NSV5 (EMBL:AE016921) (417 aa) fasta scores: E(): 1.6e-07, 33.77% id in 151 aa, and Mycobacterium paratuberculosis hypothetical protein SWALL:Q73SK8 (EMBL:AE017241) (453 aa) fasta scores: E(): 4.6e-09, 41.79% id in 134 aa.
 
 
 0.992
hemC
Putative porphobilinogen deaminase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.983
hemF
Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
 0.978
BPSL2366
Similar to Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN SWALL:HEMN_ECOLI (SWALL:P32131) (457 aa) fasta scores: E(): 3.3e-80, 47.34% id in 452 aa, and to Neisseria meningitidis oxygen-independent coproporphyrinogen III oxidase nma2108 SWALL:Q9JSW2 (EMBL:AL162758) (473 aa) fasta scores: E(): 3.6e-91, 49.56% id in 456 aa. Possible alternative translational start site; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
 
 0.954
hemH
Putative ferrochelatase protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.953
BPSL1016
Full length similar to Ralstonia solanacearum probable bifunctional: uroporphyrin-III C-methyltransferase and uroporphyrinogen-III synthase transmembrane protein rsc2356 or rs01190 SWALL:Q8XWW4 (EMBL:AL646069) (695 aa) fasta scores: E(): 1.8e-32, 39.35% id in 681 aa, and N-terminal region similar to Pseudomonas aeruginosa uroporphyrinogen-III synthase HemD or pa5259 SWALL:HEM4_PSEAE (SWALL:P48246) (251 aa) fasta scores: E(): 0.0084, 36.8% id in 269 aa, and C-terminal region to Escherichia coli putative uroporphyrin-III C-methyltransferase HemX or b3803 SWALL:HEMX_ECOLI (SWALL:P09127) ( [...]
  
 
 0.951
BPSL0961
Similar to Paracoccus denitrificans uroporphyrin-III C-methyltransferase NirE SWALL:NIRE_PARDE (SWALL:Q51701) (287 aa) fasta scores: E(): 1.3e-24, 43.75% id in 256 aa, and to the C-terminal region of Escherichia coli, and Escherichia coli O157:H7 siroheme synthase [includes: uroporphyrin-iii c-methyltransferase; precorrin-2 oxidase; ferrochelatase] CysG or b3368 or z4729 or ecs4219 SWALL:CYSG_ECOLI (SWALL:P11098) (457 aa) fasta scores: E(): 4.3e-23, 41.35% id in 237 aa.
    
 0.925
BPSS1245
Similar to Pseudomonas fluorescens uroporphyrin-III c-methyltransferase CobA SWALL:SUMT_PSEFL (SWALL:P37725) (247 aa) fasta scores: E(): 2.2e-32, 46.38% id in 235 aa, and to Xanthomonas campestris uroporphyrin-III c-methyltransferase CysG or xcc2010 SWALL:AAM41299 (EMBL:AE012305) (258 aa) fasta scores: E(): 1.5e-49, 63.55% id in 236 aa, and to Pseudomonas aeruginosa uroporphyrin-III c-methyltransferase CobA or pa1778 SWALL:Q9I2W4 (EMBL:AE004603) (245 aa) fasta scores: E(): 5e-37, 51.31% id in 228 aa; possible alternative start site at codon 41 and codon 44.
    
 0.925
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or Pa5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 2e-85, 70.3% id in 330 aa; Belongs to the ALAD family.
 
 
 0.787
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.677
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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