STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gidAGlucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (657 aa)    
Predicted Functional Partners:
trmE
Putative tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
 
 0.995
gidB
Methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
 
  
 0.993
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
 0.857
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.756
BPSL3406
Similar to Ralstonia solanacearum putative chromosome partitioning protein ParA or rsc3326 or Rs02560 SWALL:Q8XU67 (EMBL:AL646074) (261 aa) fasta scores: E(): 3.2e-75, 79.29% id in 256 aa, and to Caulobacter crescentus chromosome partitioning protein ParA or Cc3753 SWALL:PARA_CAUCR (SWALL:O05189) (267 aa) fasta scores: E(): 1.8e-43, 49.21% id in 254 aa.
       0.721
BPSL3405
Similar to Ralstonia solanacearum putative chromosome partitioning protein ParB or Rsc3325 or Rs02555 SWALL:Q8XU68 (EMBL:AL646074) (303 aa) fasta scores: E(): 2.3e-72, 73.12% id in 294 aa, and to Caulobacter crescentus chromosome partitioning protein ParB or Cc3752 SWALL:PARB_CAUCR (SWALL:O05190) (294 aa) fasta scores: E(): 3.8e-32, 42.42% id in 297 aa; Belongs to the ParB family.
  
  
 0.717
mnmC
Conserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.
   
 
 0.691
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
  
 0.671
yidC
Putative membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
  
  
 0.645
BPSL1138
Hypothetical protein; Very low similarity to the C-terminal regions of Clostridium perfringens hypothetical protein cpe1605 SWALL:Q8XJZ8 (EMBL:AP003191) (269 aa) fasta scores: E(): 1.6e-15, 32.86% id in 216 aa, and of Bacillus anthracis pxo1-131 SWALL:Q9X388 (EMBL:AF065404) (349 aa) fasta scores: E(): 6.8e-13, 32.67% id in 202 aa.
   
    0.635
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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