STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PhhBSimilar to Gallus gallus pterin-4-alpha-carbinolamine dehydratase PcdB or DcoH SWALL:PHS_CHICK (SWALL:O73930) (103 aa) fasta scores: E(): 9.8e-20, 58.51% id in 94 aa, and to Ralstonia solanacearum putative pterin-4-alpha-carbinolamine dehydratase PhhB or Rsc3356 or Rs02631 SWALL:Q8XU38 (EMBL:AL646074) (101 aa) fasta scores: E(): 2.3e-20, 58.33% id in 96 aa. (101 aa)    
Predicted Functional Partners:
phhA
Phenylalanine-4-hydroxylase; Similar to Chromobacterium violaceum phenylalanine-4-hydroxylase PhhA SWALL:PH4H_CHRVO (SWALL:P30967) (297 aa) fasta scores: E(): 1.1e-70, 62.32% id in 284 aa.
 
 0.998
BPSL3239
Similar to Pseudomonas sp. 4-hydroxyphenylpyruvate dioxygenase SWALL:HPPD_PSESP (SWALL:P80064) (357 aa) fasta scores: E(): 5.7e-37, 57.89% id in 361 aa.
 
  
 0.831
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.3e-80, 54.63% id in 399 aa, and to Pseudomonas aeruginosa aspartate aminotransferase AspC or pa3139 SWALL:AAT_PSEAE (SWALL:P72173) (398 aa) fasta scores: E(): 2.6e-111, 73.86% id in 398 aa. Note: Also similar to BPSS0808 (401 aa) fasta scores: E(): 7.1e-72, 53.149% identity in 397 aa overlap.
  
  
 0.770
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
  
 0.708
BPSL2738
Putative hydrolase; Similar to Prokaryotic and Eukaryotic hydrolases including: Ralstonia solanacearum probable fumarylacetoacetase rsp0690 or rs01759 SWALL:Q8XRZ1 (EMBL:AL646080) (423 aa) fasta scores: E(): 7.1e-116, 69.23% id in 416 aa and to Homo sapiens fumarylacetoacetase Fah SWALL:FAAA_HUMAN (SWALL:P16930) (419 aa) fasta scores: E(): 2.1e-99, 57.17% id in 411 aa.
 
  
 0.661
BPSS0339
Putative amino acid dioxygenase; Similar to Pseudomonas putida 4-hydroxyphenylpyruvate dioxygenase, putative pp2554 SWALL:AAN68163 (EMBL:AE016783) (635 aa) fasta scores: E(): 2.8e-61, 53.44% id in 683 aa. CDS contains region with additional internal amino acids (residues 272 to 338) in comparison to orthologues.
  
  
 0.589
asnO
Similar to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 3 AsnO SWALL:ASNO_BACSU (SWALL:O05272) (614 aa) fasta scores: E(): 1.6e-68, 42.01% id in 626 aa, and to Streptomyces aureofaciens asparagine synthase homolog TcsG SWALL:Q9FAR2 (EMBL:AB039379) (609 aa) fasta scores: E(): 2.6e-128, 54.76% id in 619 aa.
     
 0.554
BPSL0513
Similar to Homo sapiens maleylacetoacetate isomerase GSTZ1 or MAAI SWALL:MAAI_HUMAN (SWALL:O43708) (216 aa) fasta scores: E(): 2.5e-31, 47.39% id in 211 aa, and to Ralstonia solanacearum probable maleylacetoacetate isomerase rsc0384 or rs03352 SWALL:Q8Y2F2 (EMBL:AL646059) (216 aa) fasta scores: E(): 3.5e-54, 63.38% id in 213 aa.
 
  
 0.517
BPSS0131
Similar to Rhizobium meliloti putative epimerase dehydratase, red superfamily, possibly UDP-glucose 4-epimerase protein rb0631 or smb21052 SWALL:Q92VR8 (EMBL:AL603644) (321 aa) fasta scores: E(): 1.5e-08, 26.68% id in 311 aa, and to Streptomyces avermitilis dtdp-glucose 4,6-dehydratase AveBII SWALL:Q9S0P5 (EMBL:AB032523) (355 aa) fasta scores: E(): 1.1e-07, 25.76% id in 260 aa.
      
 0.493
tyrB1
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 2.1e-90, 58.43% id in 397 aa, and to Klebsiella pneumoniae tyrosine aminotransferase TyrB SWALL:O85746 (EMBL:AF074934) (397 aa) fasta scores: E(): 2.8e-89, 57.17% id in 397 aa. Similar to BPSS2200, 55.556% identity in 396 aa overlap, and to BPSS0355, 53.149% identity in 397 aa overlap. Note: Also similar to BPSS2200 TyrB2 (405 aa)fasta scores: E(): 4.4e-79, 55.556% identity in 396 aa overlap;. Note: Also similar to BPSS2200 (444 aa) fasta scores: E(): 4.4e-7 [...]
  
  
 0.479
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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