STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macBMacrolide-specific ABC-type efflux carrier; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (653 aa)    
Predicted Functional Partners:
BPSS0625
Putative drug-efflux protein; Similar to Escherichia coli macrolide-specific efflux protein MacA SWALL:MACA_ECOLI (SWALL:P75830) (371 aa) fasta scores: E(): 3e-34, 43.33% id in 390 aa, and to Pseudomonas syringae putative periplasmic protein SWALL:Q93NK1 (EMBL:AF372703) (389 aa) fasta scores: E(): 9.4e-54, 52.04% id in 367 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.997
BPSS0623
Similar to Pseudomonas aeruginosa outer membrane protein OprJ SWALL:OPRJ_PSEAE (SWALL:Q51397) (479 aa) fasta scores: E(): 5.6e-27, 30.22% id in 450 aa, and to Ralstonia solanacearum putative outer membrane multidrug resistance lipoprotein rsc1854 or rs05605 SWALL:Q8XYA8 (EMBL:AL646067) (475 aa) fasta scores: E(): 1.8e-29, 29.55% id in 467 aa.
 
 
 0.983
bpeA
Similar to Escherichia coli, and Escherichia coli O157:H7 acriflavine resistance protein A precursor acrA or MtcA or Lir SWALL:ACRA_ECOLI (SWALL:P31223) (397 aa) fasta scores: E(): 5.5e-60, 53.76% id in 385 aa, and to Ralstonia solanacearum probable acriflavin resistance lipoprotein A precursor rsc0011 or rs01833 SWALL:Q8Y3G9 (EMBL:AL646057) (398 aa) fasta scores: E(): 6.6e-61, 55.22% id in 402 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.976
amrA
Almost identical to Burkholderia pseudomallei putative membrane fusion protein AmrA SWALL:O87935 (EMBL:AF072887) (399 aa) fasta scores: E(): 7.7e-133, 99.74% id in 399 aa. Similar to Escherichia coli, and Escherichia coli O157:H7 acriflavine resistance protein A precursor AcrA or MtcA or Lir or b0463 or z0578 or ecs0516 SWALL:ACRA_ECO57 (SWALL:P31223) (397 aa) fasta scores: E(): 3.5e-43, 40.1% id in 384 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.954
BPSS0292
Putative multidrug efflux system exported protein; Similar to Escherichia coli, and Escherichia coli O157:H7 acriflavine resistance protein A precursor AcrA or MtcA or Lir or b0463 or z0578 or ecs0516 SWALL:ACRA_ECOLI (SWALL:P31223) (397 aa) fasta scores: E(): 5.3e-33, 32.98% id in 385 aa, and to Ralstonia solanacearum probable transmembrane multidrug efflux system transmembrane protein ys02620 or rsp1112 or rs02620 SWALL:Q8XQV6 (EMBL:AL646082) (438 aa) fasta scores: E(): 6.1e-78, 57.77% id in 405 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.948
BPSL0308
Putative exported protein; N-terminal region is similar to Salmonella typhimurium putative membrane fusion protein SilB precursor silB SWALL:SILB_SALTY (SWALL:Q9ZHD0) (430 aa) fasta scores: E(): 1.8e-37, 31.41% id in 417 aa. Full length CDS is similar to Ralstonia solanacearum putative cation efflux system transmembrane protein rsp0927 or rs05406 SWALL:Q8XRD1 (EMBL:AL646081) (513 aa) fasta scores: E(): 3.2e-51, 38.89% id in 527 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.939
BPSL1268
Similar to Ralstonia solanacearum putative resistance transmembrane protein rsp1197 or rs03141 SWALL:Q8XQM5 (EMBL:AL646083) (449 aa) fasta scores: E(): 4.6e-70, 53.22% id in 434 aa, and to Escherichia coli hypothetical protein YegM precursor or b2074 SWALL:YEGM_ECOLI (SWALL:P76397) (415 aa) fasta scores: E(): 1.3e-55, 44.96% id in 407 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.937
BPSL1568
Putative lipoprotein; Similar to Rhizobium loti component of multidrug efflux system mlr7297 SWALL:Q986M0 (EMBL:AP003011) (380 aa) fasta scores: E(): 2.8e-29, 35.97% id in 353 aa, and to Rhizobium loti rnd efflux membrane fusion protein mll5519 SWALL:Q98BL6 (EMBL:AP003006) (356 aa) fasta scores: E(): 1.4e-28, 35.53% id in 363 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.937
BPSL2234
Putative exported protein; Similar to Escherichia coli hypothetical protein precursor YegM or b2074 SWALL:YEGM_ECOLI (SWALL:P76397) (415 aa) fasta scores: E(): 2.5e-37, 36.29% id in 405 aa, and to Rhizobium loti RND efflux membrane fusion protein mll5780 SWALL:Q98B05 (EMBL:AP003007) (417 aa) fasta scores: E(): 1.5e-35, 34.54% id in 414 aa.
  
 
 0.937
czcB
Similar to Alcaligenes eutrophus cobalt-zinc-cadmium resistance protein CzcB SWALL:CZCB_ALCEU (SWALL:P13510) (520 aa) fasta scores: E(): 3.3e-73, 53.04% id in 443 aa, and to Alcaligenes sp. cation efflux system protein CzcB SWALL:CZCB_ALCSP (SWALL:P94176) (520 aa) fasta scores: E(): 1e-72, 52.59% id in 443 aa, and to Pseudomonas aeruginosa RND divalent metal cation efflux membrane fusion protein czcb precursor czcb or pa2521 SWALL:Q9I0W1 (EMBL:AE004679) (484 aa) fasta scores: E(): 1.1e-62, 45.3% id in 490 aa, and to Ralstonia solanacearum probable cobalt-zinc-cadmium resistance CzcB or [...]
  
 
 0.937
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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