STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPSS08912OG-Fe(II) oxygenase superfamily protein; Similar to Escherichia coli alkylated DNA repair protein AlkB or AidD SWALL:ALKB_ECOLI (SWALL:P05050) (216 aa) fasta scores: E(): 0.15, 30.18% id in 222 aa, and to Pseudomonas aeruginosa hypothetical protein pa3306 SWALL:Q9HYT8 (EMBL:AE004753) (200 aa) fasta scores: E(): 1.2e-33, 50.75% id in 199 aa. (208 aa)    
Predicted Functional Partners:
BPSL0100
O6-methylguanine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.
  
  
 0.593
BPSL0844
Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
    0.555
BPSL0885
Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
    0.555
BPSL1399
Putative reductase; Similar to Ralstonia solanacearum putative oxidoreductase protein rsc3361 or rs02636 SWALL:Q8XU33 (EMBL:AL646074) (325 aa) fasta scores: E(): 2.4e-50, 51.5% id in 332 aa, and to Rhizobium loti putative 2-dehydropantoate 2-reductase mll6982 SWALL:PANE_RHILO (SWALL:Q987N5) (326 aa) fasta scores: E(): 2.2e-43, 45.59% id in 329 aa.
   
    0.555
BPSS0890
Nitroreductase family protein; Similar to Xanthomonas axonopodis putative NADH dehydrogenase/NAD(P)H nitroreductase xac0554 SWALL:AAM35443 (EMBL:AE011683) (198 aa) fasta scores: E(): 1.2e-53, 74.24% id in 198 aa, and to Xanthomonas campestris putative NADH dehydrogenase/NAD(P)H nitroreductase xcc3605 SWALL:AAM42875 (EMBL:AE012481) (196 aa) fasta scores: E(): 1.8e-53, 74.34% id in 191 aa.
       0.554
BPSS0892
Similar to Pseudomonas putida Pca regulon regulatory protein PcaR SWALL:PCAR_PSEPU (SWALL:Q52154) (291 aa) fasta scores: E(): 4.9e-15, 26.25% id in 278 aa. C-terminal region is similar to Pseudomonas aeruginosa probable transcriptional regulator pa3508 SWALL:Q9HYA1 (EMBL:AE004771) (277 aa) fasta scores: E(): 1.2e-41, 49.09% id in 275 aa. Similar to BPSS0900, 64.184% identity (65.108% ungapped) in 282 aa overlap.
       0.547
BPSL1725
Conserved hypothetical protein; Full length similar to C-terminal region of Drosophila melanogaster CG13902 protein SWALL:Q9W0M3 (EMBL:AE003469) (394 aa) fasta scores: E(): 7.6e-16, 28.68% id in 244 aa, and C-terminal region similar to C-terminal region of Caulobacter crescentus PasS1-related protein cc1001 SWALL:Q9A9H9 (EMBL:AE005778) (344 aa) fasta scores: E(): 8.7e-08, 29.95% id in 207 aa. Note: Most of the database hits are to eukaryotic entries.
  
     0.503
BPSS0339
Putative amino acid dioxygenase; Similar to Pseudomonas putida 4-hydroxyphenylpyruvate dioxygenase, putative pp2554 SWALL:AAN68163 (EMBL:AE016783) (635 aa) fasta scores: E(): 2.8e-61, 53.44% id in 683 aa. CDS contains region with additional internal amino acids (residues 272 to 338) in comparison to orthologues.
  
    0.424
BPSS0889
Calcineurin-like phosphoesterase; Similar to Helicobacter pylori J99 hypothetical protein JHP0380 SWALL:YA44_HELPJ (SWALL:Q9ZM43) (370 aa) fasta scores: E(): 3.4e-24, 31.86% id in 386 aa, and to Campylobacter jejuni hypothetical protein CJ0846 SWALL:Y846_CAMJE (SWALL:Q9PP77) (374 aa) fasta scores: E(): 2.7e-23, 32.22% id in 391 aa.
       0.421
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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