STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bopEPutative G-nucleotide exchange factor; Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells. (261 aa)    
Predicted Functional Partners:
bipD
Putative membrane antigen; Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane; Belongs to the invasin protein D family.
   
  
 0.942
bipB
Putative cell invasion protein; Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes.
   
  
 0.877
bopA
Putative intercellular spread protein; Plays a role in mediating bacterial evasion from the host autophagic pathway; Belongs to the BopA/IcsB family.
      
 0.685
bsaQ
Type III secretion system protein; Similar to Salmonella typhimurium, and Salmonella typhi invasion protein InvA or stm2896 or sty3019 SWALL:INVA_SALTY (SWALL:P35657) (685 aa) fasta scores: E(): 7.7e-135, 56.05% id in 694 aa, and to Shigella flexneri, and Shigella sonnei MxiA protein or VirH or cp0147 SWALL:MXIA_SHIFL (SWALL:P35533) (686 aa) fasta scores: E(): 5.3e-133, 55.57% id in 691 aa.
   
  
 0.629
bsaP
Type III secretion system protein; Similar to Salmonella typhimurium invasion protein InvE or stm2897 SWALL:INVE_SALTY (SWALL:P35671) (372 aa) fasta scores: E(): 3.8e-24, 33.81% id in 346 aa.
   
  
 0.600
BPSS1547
Type III secretion system protein; Similar to Salmonella typhimurium PrgH protein or stm2874 SWALL:PRGH_SALTY (SWALL:P41783) (392 aa) fasta scores: E(): 9.1e-12, 23.74% id in 417 aa, and to Salmonella typhi pathogenicity 1 island effector protein PrgH or sty2995 SWALL:Q8Z499 (EMBL:AL627276) (392 aa) fasta scores: E(): 7e-12, 24.46% id in 417 aa.
   
  
 0.589
bsaZ
Surface presentation of antigens protein; Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell. Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm.
   
  
 0.529
bapC
Similar to Salmonella typhi invasion protein IagB or sty3000 SWALL:IAGB_SALTI (SWALL:P43018) (160 aa) fasta scores: E(): 2e-11, 42.27% id in 123 aa, and to Burkholderia pseudomallei hypothetical 18.2 kDa protein SWALL:Q9ZF87 (EMBL:AF110185) (161 aa) fasta scores: E(): 5.2e-21, 47.68% id in 151 aa.
   
  
 0.507
bapB
Acyl carrier protein; Similar to Saccharopolyspora erythraea acyl carrier protein AcpP SWALL:ACP_SACER (SWALL:P11830) (95 aa) fasta scores: E(): 0.0043, 36.84% id in 76 aa, and to Thermotoga maritima acyl carrier protein AcpP or tm0662 SWALL:Q9WZD0 (EMBL:AE001739) (81 aa) fasta scores: E(): 9.7e-05, 31.88% id in 69 aa.
   
  
 0.476
bsaR
Similar to Salmonella typhimurium, and Salmonella typhi surface presentation of antigens protein SpaK or InvB or stm2895 or sty3018 SWALL:SPAK_SALTY (SWALL:P39443) (135 aa) fasta scores: E(): 4e-06, 27.61% id in 134 aa, and to Shigella sonnei surface presentation of antigens protein spak spak or spa15 SWALL:SPAK_SHISO (SWALL:Q55296) (133 aa) fasta scores: E(): 1.9e-05, 26.51% id in 132 aa.
   
  
 0.444
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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