STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folE2Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (269 aa)    
Predicted Functional Partners:
folE-2
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SWALL:GCH1_BACSU (SWALL:P19465) (190 aa) fasta scores: E(): 2.9e-19, 33.33% id in 189 aa, and to Ralstonia solanacearum GTP cyclohydrolase I FolE or rsc1387 or rs04670 SWALL:Q8XZK8 (EMBL:AL646064) (209 aa) fasta scores: E(): 7.5e-67, 84.12% id in 189 aa.
     
 0.947
folE-3
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SWALL:GCH1_BACSU (SWALL:P19465) (190 aa) fasta scores: E(): 1.8e-19, 36.11% id in 180 aa, and to Ralstonia solanacearum GTP cyclohydrolase I FolE or rsc1387 or rs04670 SWALL:Q8XZK8 (EMBL:AL646064) (209 aa) fasta scores: E(): 6.2e-66, 83.59% id in 189 aa, and to Mycobacterium leprae GTP cyclohydrolase I FolE or ml0223 or mlcb2548.08C SWALL:GCH1_MYCLE (SWALL:O69531) (205 aa) fasta scores: E(): 3.1e-20, 38.34% id in 193 aa.
     
 0.940
BPSL0179
6-pyruvoyl tetrahydropterin synthase; Similar to Ralstonia solanacearum putative 6-pyruvoyl tetrahydrobiopterin synthase protein rsc1450 or rs03857 SWALL:Q8XZF1 (EMBL:AL646064) (158 aa) fasta scores: E(): 1.1e-34, 65.27% id in 144 aa, and to Neisseria meningitidis hypothetical protein NMA0704 SWALL:Q9JVT6 (EMBL:AL162754) (140 aa) fasta scores: E(): 3e-13, 39.18% id in 148 aa.
    
 0.933
folE
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SWALL:GCH1_BACSU (SWALL:P19465) (190 aa) fasta scores: E(): 1.6e-29, 47.64% id in 170 aa, and to Xanthomonas campestris GTP cyclohydrolase I xcc4166 SWALL:GCH1_XANCP (SWALL:Q8P3B0) (200 aa) fasta scores: E(): 5.6e-45, 65.69% id in 172 aa. Note: This CDS has a possible alternative start codon 156 residues upstream.
     
 0.933
ribB-2
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
     
 0.909
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
     
 0.902
RibA
Similar to Photobacterium phosphoreum GTP cyclohydrolase II RibA SWALL:GCH2_PHOPO (SWALL:P51618) (200 aa) fasta scores: E(): 5.1e-37, 52.47% id in 202 aa, and to Pseudomonas glumae GTP cyclohydrolase II toxB SWALL:Q8RS38 (EMBL:AB040403) (212 aa) fasta scores: E(): 3.4e-64, 77.22% id in 202 aa, and to Vibrio cholerae GTP cyclohydrolase II vc1263 SWALL:Q9KSJ3 (EMBL:AE004205) (216 aa) fasta scores: E(): 1e-41, 54.8% id in 208 aa. Possible translational start site after codon 9.
     
 0.902
BPSL0360
Putative alkaline phosphatase; Similar to an internal region of Homo sapiens alkaline phosphatase, placental type 1 precursor ALPP or PLAP SWALL:PPB1_HUMAN (SWALL:P05187) (535 aa) fasta scores: E(): 2e-16, 37.23% id in 470 aa, and to the full length Ralstonia solanacearum putative alkaline phosphatase lipoprotein transmembrane rsc0097 or rs02267 SWALL:Q8Y383 (EMBL:AL646057) (483 aa) fasta scores: E(): 2e-99, 63.03% id in 487 aa. Similar to BPSL0361, 56.639% identity (61.625% ungapped) in 482 aa overlap.
     
  0.900
BPSL0361
Putative alkaline phosphatase; Similar to an internal region of Homo sapiens alkaline phosphatase, placental type 1 precursor ALPP or PLAP SWALL:PPB1_HUMAN (SWALL:P05187) (535 aa) fasta scores: E(): 2.7e-32, 35.45% id in 471 aa, and to the full length Ralstonia solanacearum putative alkaline phosphatase signal peptide protein rsc0098 or rs02280 SWALL:Q8Y382 (EMBL:AL646057) (467 aa) fasta scores: E(): 1.6e-98, 62.92% id in 472 aa. Similar to BPSL0360, 56.432% identity (61.400% ungapped) in 482 aa overlap.
     
  0.900
NtpA
Similar to Escherichia coli dATP pyrophosphohydrolase NudB or NtpA SWALL:NUDB_ECOLI (SWALL:P24236) (150 aa) fasta scores: E(): 8.2e-16, 44.82% id in 145 aa, and to Ralstonia solanacearum probable datp pyrophosphohydrolase protein rsc0468 or rs04429 SWALL:Q8Y268 (EMBL:AL646059) (162 aa) fasta scores: E(): 8.4e-36, 64.55% id in 158 aa.
     
  0.900
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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