STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsdASimilar to Escherichia coli D-serine dehydratase DsdA or b2366 SWALL:SDHD_ECOLI (SWALL:P00926) (442 aa) fasta scores: E(): 4.4e-63, 44.75% id in 429 aa, and to Pseudomonas aeruginosa probable D-serine dehydratase DsdA or pa3357 SWALL:Q9HYN9 (EMBL:AE004758) (448 aa) fasta scores: E(): 3.8e-69, 50.46% id in 430 aa, and to Bacillus subtilis probable D-serine dehydratase DsdA SWALL:SDHD_BACSU (SWALL:P54555) (448 aa) fasta scores: E(): 1.1e-63, 45.81% id in 430 aa; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (445 aa)    
Predicted Functional Partners:
sdaA
Similar to Escherichia coli L-serine dehydratase 1 SdaA or b1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 1.7e-86, 52.7% id in 463 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
 0.915
sdaB
Similar to Escherichia coli L-serine dehydratase 2 SdaB or b2797 SWALL:SDHM_ECOLI (SWALL:P30744) (455 aa) fasta scores: E(): 1.3e-84, 50.86% id in 462 aa, and to Ralstonia solanacearum probable L-serine dehydratase SdaA1 or rsp0045 or rs02020 SWALL:Q8XTR1 (EMBL:AL646076) (461 aa) fasta scores: E(): 1.1e-162, 90.88% id in 461 aa, and to Ralstonia solanacearum probable L-serine dehydratase SdaA2 or rsc3296 or rs02527 SWALL:Q8XU97 (EMBL:AL646074) (458 aa) fasta scores: E(): 5.4e-121, 67.89% id in 461 aa.
     
 0.915
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.908
BPSL2102
Putative threonine dehydratase; Similar to Escherichia coli, and Escherichia coli O157:H7 threonine dehydratase catabolic TdcB or b3117 or z4469 or ecs3997 SWALL:THD2_ECOLI (SWALL:P05792) (329 aa) fasta scores: E(): 1.8e-29, 36.9% id in 317 aa, and to Streptomyces coelicolor putative threonine dehydratase sco0821 or scf43a.11C SWALL:Q9XAA4 (EMBL:AL096837) (325 aa) fasta scores: E(): 8.4e-34, 37.81% id in 320 aa.
     
 0.908
ilvA-2
Putative threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.908
BPSL0628
Conserved hypothetical protein; Similar to Burkholderia cepacia D-serine deaminase Dsd SWALL:Q45085 (EMBL:AF158699) (432 aa) fasta scores: E(): 8.8e-141, 82.39% id in 426 aa, and to Ralstonia solanacearum probable D-serine deaminase rsp1185 or rs03129 SWALL:Q8XQN7 (EMBL:AL646083) (425 aa) fasta scores: E(): 8.3e-112, 66.9% id in 429 aa.
     
  0.900
BPSL0334
Conserved hypothetical protein; Similar to Ralstonia solanacearum putative 2-hydroxyacid dehydrogenase oxidoreductase protein rsc0262 or rs00697 SWALL:Q8Y2S3 (EMBL:AL646058) (313 aa) fasta scores: E(): 5.5e-65, 57.5% id in 313 aa, and to Salmonella typhi putative 2-hydroxyacid dehydrogenase in phoH-csgG intergenic region sty1172 SWALL:Q8Z7M6 (EMBL:AL627269) (312 aa) fasta scores: E(): 1.6e-54, 50.16% id in 313 aa.
     
  0.800
gloA
Lactoylglutathione lyase; Similar to Neisseria meningitidis lactoylglutathione lyase GloA SWALL:LGUL_NEIMA (SWALL:O33393) (138 aa) fasta scores: E(): 1.4e-39, 75% id in 128 aa, and to Pseudomonas aeruginosa lactoylglutathione lyase PA3524 SWALL:Q9HY85 (EMBL:AE004773) (128 aa) fasta scores: E(): 6.3e-38, 71.87% id in 128 aa.
     
  0.800
tkrA
Similar to Erwinia herbicola 2-ketogluconate reductase TkrA SWALL:TKRA_ERWHE (SWALL:P58000) (323 aa) fasta scores: E(): 3.7e-57, 54.79% id in 323 aa, and to Yersinia pestis putative D-isomer specific 2-hydroxyacid dehydrogenase ypo4078 SWALL:Q8Z9W1 (EMBL:AJ414160) (326 aa) fasta scores: E(): 5.6e-64, 58.51% id in 323 aa.
     
  0.800
BPSL2459
Similar to Escherichia coli 2-ketogluconate reductase TkrA SWALL:TKRA_ECOLI (SWALL:P37666) (324 aa) fasta scores: E(): 1.6e-39, 41.71% id in 326 aa, and to Ralstonia solanacearum probable dehydrogenase oxidoreductase protein rsc1034 or rs04216 SWALL:Q8Y0K9 (EMBL:AL646062) (334 aa) fasta scores: E(): 1.8e-81, 68.5% id in 327 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
  0.800
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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