node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA_C1717 | gmk | CA_C1717 | CA_C1718 | Uncharacterized conserved protein, YLOA ortholog; Belongs to the RemA family. | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | 0.968 |
CA_C1717 | rpoZ | CA_C1717 | CA_C1719 | Uncharacterized conserved protein, YLOA ortholog; Belongs to the RemA family. | RNA polymerase-associated protein RpoZ, omega subunit (YLOH B.subtilis ortholog); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.876 |
apt | gmk | CA_C2275 | CA_C1718 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | 0.942 |
apt | guaA | CA_C2275 | CA_C2700 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.990 |
apt | guaC | CA_C2275 | CA_C3471 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.979 |
apt | hprT | CA_C2275 | CA_C3203 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.940 |
apt | spoT | CA_C2275 | CA_C2274 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | RelA/SpoT protein, (p)ppGpp synthetase/pyrophosphohydrolases; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.686 |
apt | xpt | CA_C2275 | CA_C0873 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.978 |
gmk | CA_C1717 | CA_C1718 | CA_C1717 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Uncharacterized conserved protein, YLOA ortholog; Belongs to the RemA family. | 0.968 |
gmk | apt | CA_C1718 | CA_C2275 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.942 |
gmk | guaA | CA_C1718 | CA_C2700 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.969 |
gmk | guaC | CA_C1718 | CA_C3471 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.910 |
gmk | hprT | CA_C1718 | CA_C3203 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
gmk | pykA | CA_C1718 | CA_C0518 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase (pykA). | 0.930 |
gmk | pykA-2 | CA_C1718 | CA_C1036 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.911 |
gmk | rpoZ | CA_C1718 | CA_C1719 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | RNA polymerase-associated protein RpoZ, omega subunit (YLOH B.subtilis ortholog); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.984 |
gmk | spoT | CA_C1718 | CA_C2274 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | RelA/SpoT protein, (p)ppGpp synthetase/pyrophosphohydrolases; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.917 |
gmk | xpt | CA_C1718 | CA_C0873 | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.950 |
guaA | apt | CA_C2700 | CA_C2275 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.990 |
guaA | gmk | CA_C2700 | CA_C1718 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. | 0.969 |