node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpC | clpP | CA_C3189 | CA_C2640 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.968 |
clpC | dnaJ | CA_C3189 | CA_C1283 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Molecular chaperones DnaJ (HSP40 family); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactio [...] | 0.864 |
clpC | dnaK | CA_C3189 | CA_C0472 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | DnaK protein (heat shock protein), HSP70/DnaK family. | 0.914 |
clpC | dnaK-2 | CA_C3189 | CA_C0473 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | DnaK protein (heat shock protein), C-terminal region has VWA type A domain; Belongs to the heat shock protein 70 family. | 0.902 |
clpC | dnaK-3 | CA_C3189 | CA_C1282 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK, HSP70 family; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.942 |
clpC | groEL | CA_C3189 | CA_C2703 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Chaperonin GroEL, HSP60 family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.827 |
clpC | groES | CA_C3189 | CA_C2704 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES, HSP10 family; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.820 |
clpC | grpE | CA_C3189 | CA_C1281 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.844 |
clpC | hrcA | CA_C3189 | CA_C1280 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Transcriptional regulator of heat shock genes, HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons; Belongs to the HrcA family. | 0.919 |
clpC | htpG | CA_C3189 | CA_C3315 | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | Molecular chaperone, HSP90 family; Molecular chaperone. Has ATPase activity. | 0.845 |
clpP | clpC | CA_C2640 | CA_C3189 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATPases with chaperone activity clpC, two ATP-binding domain; Belongs to the ClpA/ClpB family. | 0.968 |
clpP | dnaJ | CA_C2640 | CA_C1283 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperones DnaJ (HSP40 family); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactio [...] | 0.626 |
clpP | dnaK | CA_C2640 | CA_C0472 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK protein (heat shock protein), HSP70/DnaK family. | 0.810 |
clpP | dnaK-2 | CA_C2640 | CA_C0473 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaK protein (heat shock protein), C-terminal region has VWA type A domain; Belongs to the heat shock protein 70 family. | 0.741 |
clpP | dnaK-3 | CA_C2640 | CA_C1282 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone DnaK, HSP70 family; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.850 |
clpP | groEL | CA_C2640 | CA_C2703 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperonin GroEL, HSP60 family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.893 |
clpP | groES | CA_C2640 | CA_C2704 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Co-chaperonin GroES, HSP10 family; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.906 |
clpP | grpE | CA_C2640 | CA_C1281 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.878 |
clpP | hrcA | CA_C2640 | CA_C1280 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator of heat shock genes, HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons; Belongs to the HrcA family. | 0.861 |
clpP | htpG | CA_C2640 | CA_C3315 | Protease subunits of ATP-dependent protease, ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone, HSP90 family; Molecular chaperone. Has ATPase activity. | 0.732 |