node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA_C0291 | folA | CA_C0291 | CA_C3004 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
CA_C0291 | folC | CA_C0291 | CA_C2398 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.441 |
CA_C0291 | folD | CA_C0291 | CA_C2083 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. | Tetrahydrofolate dehydrogenase/cyclohydrolase, FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
CA_C0291 | glyA | CA_C0291 | CA_C2264 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
CA_C0291 | thyA | CA_C0291 | CA_C3003 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.951 |
CA_C0353 | CA_C2876 | CA_C0353 | CA_C2876 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | Deoxycytidylate deaminase. | 0.905 |
CA_C0353 | dut | CA_C0353 | CA_C1210 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
CA_C0353 | dut-2 | CA_C0353 | CA_C1425 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | DUTPase, dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
CA_C0353 | tdk | CA_C0353 | CA_C2887 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | Thymidine kinase; Belongs to the thymidine kinase family. | 0.918 |
CA_C0353 | thyA | CA_C0353 | CA_C3003 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.904 |
CA_C2876 | CA_C0353 | CA_C2876 | CA_C0353 | Deoxycytidylate deaminase. | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | 0.905 |
CA_C2876 | dut | CA_C2876 | CA_C1210 | Deoxycytidylate deaminase. | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.933 |
CA_C2876 | dut-2 | CA_C2876 | CA_C1425 | Deoxycytidylate deaminase. | DUTPase, dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.933 |
CA_C2876 | glyA | CA_C2876 | CA_C2264 | Deoxycytidylate deaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.418 |
CA_C2876 | tdk | CA_C2876 | CA_C2887 | Deoxycytidylate deaminase. | Thymidine kinase; Belongs to the thymidine kinase family. | 0.934 |
CA_C2876 | thyA | CA_C2876 | CA_C3003 | Deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
dut | CA_C0353 | CA_C1210 | CA_C0353 | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). | 0.900 |
dut | CA_C2876 | CA_C1210 | CA_C2876 | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Deoxycytidylate deaminase. | 0.933 |
dut | dut-2 | CA_C1210 | CA_C1425 | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | DUTPase, dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.911 |
dut | tdk | CA_C1210 | CA_C2887 | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase; Belongs to the thymidine kinase family. | 0.957 |