STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIIEStage II sporulation protein E, serine phosphatase family. (795 aa)    
Predicted Functional Partners:
spoIIGA
Sigma factor E processing enzyme, SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR (By similarity). Belongs to the peptidase U4 family.
  
  
 0.986
spoIIAB
Sigma factor F inhibitor spoIIAB (anti-sigma factor); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.972
SpoIIP
Stage II sporulation protein P.
  
   
 0.959
spo0A
Spo0A protein, (CheY-like receiver domain and HTH-type DNA binding domain); May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process (By similarity).
  
  
 0.959
spoIIR
Stage II sporulation protein R.
  
   
 0.956
spoIIID
Stage III sporulation protein D, SpoIIID.
  
   
 0.947
spoIIAA
Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family.
  
  
 0.898
sigG
Specialized DNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes.
  
  
 0.888
CA_C1713
Coat morphogenesis sporulation protein spoIVA; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.823
CA_C2093
Stage III sporulation protein AA, SpoIIIAA.
  
   
 0.822
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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