node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA_C2452 | CA_C2777 | CA_C2452 | CA_C2777 | Flavodoxin. | Glutaredoxin. | 0.612 |
CA_C2452 | dfx | CA_C2452 | CA_C2450 | Flavodoxin. | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | 0.863 |
CA_C2452 | fprA1 | CA_C2452 | CA_C1027 | Flavodoxin. | Flavoprotein; Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. | 0.599 |
CA_C2452 | nroR | CA_C2452 | CA_C2448 | Flavodoxin. | NAD(FAD)-dependent dehydrogenase, NirB-family (N-terminal domain); Catalyzes the NADH-dependent reduction of rubredoxin (Rd). NADPH is a very poor electron donor compared to NADH. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2. Also functions as an intermediate component in the electron transfer chains from NADH to revRbr and Dfx. Therefore, is a key electron carrier in an efficient multienzyme complex that can scavenge O(2) and reactive oxygen species (ROS), and thus plays an important role in the oxidative stress defense system in C.ace [...] | 0.813 |
CA_C2452 | rbr3A | CA_C2452 | CA_C3598 | Flavodoxin. | Rubrerythrin; Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries from NADH to revRbr 1. Plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Also exhibits NADH oxidase (NADH:O(2) oxidoreductase) activity in vitro, which is 100-fold lesser than that of FprA1/2 using the same electron transfer components. Therefore, its predominant function is most likely as a scavenger of its prefer [...] | 0.512 |
CA_C2452 | rbr3B | CA_C2452 | CA_C3597 | Flavodoxin. | Rubrerythrin; Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) as the electron transport intermediary from NADH to revRbr 2. Plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Also exhibits NADH oxidase (NADH:O(2) oxidoreductase) activity in vitro, which is 100-fold lesser than that of FprA1/2 using the same electron transfer components. Therefore, its predominant function is most likely as a scavenger of its preferred substrate, H(2)O(2). | 0.512 |
CA_C2452 | rd | CA_C2452 | CA_C2778 | Flavodoxin. | Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2 in which Rd serves as the proximal electron donor to the FDPs that exhibit H(2)O-forming NADH oxidase activity. Also functions as the proximal electron donor to the Dfx and revRbr proteins that display superoxide reductase (SOR) and NADH peroxidase activity, respectively. Therefore, is [...] | 0.560 |
CA_C2777 | CA_C2452 | CA_C2777 | CA_C2452 | Glutaredoxin. | Flavodoxin. | 0.612 |
CA_C2777 | dfx | CA_C2777 | CA_C2450 | Glutaredoxin. | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | 0.636 |
CA_C2777 | fprA1 | CA_C2777 | CA_C1027 | Glutaredoxin. | Flavoprotein; Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. | 0.469 |
CA_C2777 | fprA2 | CA_C2777 | CA_C2449 | Glutaredoxin. | Predicted flavoprotein; Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Can also serve as the terminal component of an NADH:nitric oxide oxidoreductase (NOR) with a catalytic efficiency com [...] | 0.681 |
CA_C2777 | nroR | CA_C2777 | CA_C2448 | Glutaredoxin. | NAD(FAD)-dependent dehydrogenase, NirB-family (N-terminal domain); Catalyzes the NADH-dependent reduction of rubredoxin (Rd). NADPH is a very poor electron donor compared to NADH. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2. Also functions as an intermediate component in the electron transfer chains from NADH to revRbr and Dfx. Therefore, is a key electron carrier in an efficient multienzyme complex that can scavenge O(2) and reactive oxygen species (ROS), and thus plays an important role in the oxidative stress defense system in C.ace [...] | 0.704 |
CA_C2777 | rbr3A | CA_C2777 | CA_C3598 | Glutaredoxin. | Rubrerythrin; Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries from NADH to revRbr 1. Plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Also exhibits NADH oxidase (NADH:O(2) oxidoreductase) activity in vitro, which is 100-fold lesser than that of FprA1/2 using the same electron transfer components. Therefore, its predominant function is most likely as a scavenger of its prefer [...] | 0.636 |
CA_C2777 | rbr3B | CA_C2777 | CA_C3597 | Glutaredoxin. | Rubrerythrin; Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) as the electron transport intermediary from NADH to revRbr 2. Plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Also exhibits NADH oxidase (NADH:O(2) oxidoreductase) activity in vitro, which is 100-fold lesser than that of FprA1/2 using the same electron transfer components. Therefore, its predominant function is most likely as a scavenger of its preferred substrate, H(2)O(2). | 0.598 |
CA_C2777 | rd | CA_C2777 | CA_C2778 | Glutaredoxin. | Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2 in which Rd serves as the proximal electron donor to the FDPs that exhibit H(2)O-forming NADH oxidase activity. Also functions as the proximal electron donor to the Dfx and revRbr proteins that display superoxide reductase (SOR) and NADH peroxidase activity, respectively. Therefore, is [...] | 0.878 |
dfx | CA_C2452 | CA_C2450 | CA_C2452 | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | Flavodoxin. | 0.863 |
dfx | CA_C2777 | CA_C2450 | CA_C2777 | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | Glutaredoxin. | 0.636 |
dfx | fprA1 | CA_C2450 | CA_C1027 | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | Flavoprotein; Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. | 0.881 |
dfx | fprA2 | CA_C2450 | CA_C2449 | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | Predicted flavoprotein; Catalyzes the four-electron reduction of molecular oxygen to water. In fact, functions as the terminal component of an NADH oxidase (NADH:O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and FDP. Is thus able to reductively scavenge intracellular dioxygen and is part of an oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Can also serve as the terminal component of an NADH:nitric oxide oxidoreductase (NOR) with a catalytic efficiency com [...] | 0.947 |
dfx | nroR | CA_C2450 | CA_C2448 | Desulfoferrodoxin; Catalyzes the reduction of superoxide to hydrogen peroxide, using electrons from NADH and NADH:rubredoxin oxidoreductase (NROR) and rubredoxin (Rd) as electron transport intermediaries between NADH and Dfx. Is a key factor in the superoxide reductase dependent part of a pathway for detoxification of reactive oxygen species (ROS) in C.acetobutylicum, an obligate anaerobic bacterium. | NAD(FAD)-dependent dehydrogenase, NirB-family (N-terminal domain); Catalyzes the NADH-dependent reduction of rubredoxin (Rd). NADPH is a very poor electron donor compared to NADH. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2. Also functions as an intermediate component in the electron transfer chains from NADH to revRbr and Dfx. Therefore, is a key electron carrier in an efficient multienzyme complex that can scavenge O(2) and reactive oxygen species (ROS), and thus plays an important role in the oxidative stress defense system in C.ace [...] | 0.894 |