STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccpATranscriptional regulator, LacI family; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651 .Experimentally verified as part of mature spore proteome PMID:19542279. (338 aa)    
Predicted Functional Partners:
ptsH
PTS system, HPr protein.
   
 
 0.793
codY
Transcriptional regulator, GTP-sensing pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
   
 
 0.757
serA
Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
      
 0.691
spo0A
Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
      
 0.677
sigH
RNA polymerase factor sigma-70.
   
  
 0.650
tcdR
Alternative RNA polymerase sigma factors.
   
  
 0.643
pyk
Pyruvate kinase (PK); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the pyruvate kinase family.
   
 
 0.640
tcdB
Toxin B.
      
 0.610
prdR
Transcriptional regulator, sigma-54-dependent.
      
 0.574
guaA
Fragment of conserved hypothetical protein,DUF111 family; Catalyzes the synthesis of GMP from XMP.
   
   0.569
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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