STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folA1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (185 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.977
thyX
Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.962
purU
Formyltetrahydrofolate deformylase.
 
  
 0.939
purH
Bifunctional purine biosynthesis protein PurH; Includes phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase) and IMP cyclohydrolase.
    
 0.934
folP
Dihydropteroate synthase.
    
 0.931
gcvT2
Probable aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.928
gcvT4
Aminomethyltransferase.
  
 
 0.928
rrnAC0858
Arylsulfatase.
       0.773
tmk
Thymidylate kinase.
     
 0.740
katG2
Peroxidase/catalase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
     
 0.738
Your Current Organism:
Haloarcula marismortui
NCBI taxonomy Id: 272569
Other names: H. marismortui ATCC 43049, Haloarcula marismortui ATCC 43049, Haloarcula marismortui str. ATCC 43049, Haloarcula marismortui strain ATCC 43049
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