| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fapJ | tatD | rrnAC2183 | rrnAC1504 | Flagella accessory protein J. | TatD related DNase. | 0.737 |
| mptD | nmd3 | rrnAC2306 | rrnAC2903 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Putative nonsense mediated mRNA decay protein. | 0.527 |
| mptD | rpl40E | rrnAC2306 | rrnAC2802 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.538 |
| mptD | rpl44E | rrnAC2306 | rrnAC3514 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 50S ribosomal protein L44E; Binds to the 23S rRNA. Binds deacetylated tRNA in the E site; when the tRNA binds a stretch of 7 amino acids are displaced to allow binding. | 0.519 |
| mptD | rrnAC1064 | rrnAC2306 | rrnAC1064 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Unknown; Belongs to the UPF0179 family. | 0.732 |
| mptD | rrnAC3263 | rrnAC2306 | rrnAC3263 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Unknown. | 0.677 |
| mptD | tatD | rrnAC2306 | rrnAC1504 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | TatD related DNase. | 0.629 |
| mptD | tgt-2 | rrnAC2306 | rrnAC3261 | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | Archaeosine tRNA-ribosyltransferase. | 0.551 |
| mvk | rnz | rrnAC0077 | rrnAC2500 | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | Metallo-beta-lactamase-like; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.845 |
| mvk | tatD | rrnAC0077 | rrnAC1504 | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | TatD related DNase. | 0.690 |
| nmd3 | mptD | rrnAC2903 | rrnAC2306 | Putative nonsense mediated mRNA decay protein. | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.527 |
| nmd3 | rpl40E | rrnAC2903 | rrnAC2802 | Putative nonsense mediated mRNA decay protein. | 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.957 |
| nmd3 | rpl44E | rrnAC2903 | rrnAC3514 | Putative nonsense mediated mRNA decay protein. | 50S ribosomal protein L44E; Binds to the 23S rRNA. Binds deacetylated tRNA in the E site; when the tRNA binds a stretch of 7 amino acids are displaced to allow binding. | 0.950 |
| nmd3 | rrnAC1064 | rrnAC2903 | rrnAC1064 | Putative nonsense mediated mRNA decay protein. | Unknown; Belongs to the UPF0179 family. | 0.626 |
| nmd3 | rrnAC3263 | rrnAC2903 | rrnAC3263 | Putative nonsense mediated mRNA decay protein. | Unknown. | 0.653 |
| nmd3 | tatD | rrnAC2903 | rrnAC1504 | Putative nonsense mediated mRNA decay protein. | TatD related DNase. | 0.714 |
| nmd3 | tgt-2 | rrnAC2903 | rrnAC3261 | Putative nonsense mediated mRNA decay protein. | Archaeosine tRNA-ribosyltransferase. | 0.739 |
| rnz | mvk | rrnAC2500 | rrnAC0077 | Metallo-beta-lactamase-like; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.845 |
| rnz | tatD | rrnAC2500 | rrnAC1504 | Metallo-beta-lactamase-like; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | TatD related DNase. | 0.690 |
| rpl40E | mptD | rrnAC2802 | rrnAC2306 | 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. | Unknown; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.538 |